{"product_id":"abcam-ab85726","title":"Abcam, ab85726, Anti-ANKRD17 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal ANKRD17 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ANKRD17 aa 750-850.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ANKRD17 aa 750-850. The exact immunogen used to generate this antibody is proprietary information.O75179\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nANKRD17 also known as Ankyrin Repeat Domain-containing protein 17 performs key mechanical roles within the cell. This protein weighs around 260 kDa. ANKRD17 is found throughout the human body with notable expression in the brain and liver. It functions importantly in the regulation of cell cycle and nucleocytoplasmic transport through its ankyrin repeat domains which allow interactions with other proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nANKRD17 engages in processes such as gene expression regulation and immune response. It is a member of protein complexes involved in these pathways. ANKRD17 modulates the transcriptional activity of certain genes and plays a part in antiviral response due to its role in signaling pathways that detect viral infections. These roles reflect its significance in maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nANKRD17 participates mainly in the NF-κB and p53 signaling pathways. In the NF-κB pathway ANKRD17 interacts with proteins like IκB facilitating processes that control inflammation and immune responses. In the p53 pathway it associates with the p53 protein regulating cell cycle arrest and apoptosis. Its involvement in these pathways highlights its function in monitoring cell integrity and response to stress or damage.\u003cbr\u003e\nANKRD17 has associations with hepatocellular carcinoma and viral infections. It interacts with tumor suppressor proteins like p53 where its altered function can contribute to cancer development by affecting cell cycle control and apoptosis. In viral infections such as influenza ANKRD17's role in immune signaling can impact the body's ability to effectively respond to pathogens. Understanding these connections emphasizes its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853991006377,"sku":"ab85726","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab85726","provider":"Iright","version":"1.0","type":"link"}