{"product_id":"abcam-ab85727","title":"Abcam, ab85727, Anti-ARSB antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nGoat Polyclonal ARSB antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ARSB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Goat,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ARSB. The exact immunogen used to generate this antibody is proprietary information.P15848\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe ARSB protein also known as arylsulfatase B or N-acetylgalactosamine-4-sulfatase is an enzyme weighing approximately 62 kDa. It plays a role in breaking down glycosaminoglycans in the lysosomes. ARSB is highly expressed in tissues such as the liver kidney and skin where its enzymatic activity is important for normal cellular metabolism.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nARSB functions in the degradation of dermatan sulfate and chondroitin sulfate types of glycosaminoglycans. It works as a monomer and is not part of a larger protein complex. This enzyme targets specific sulfated molecules facilitating their breakdown and recycling within the lysosomes.\u003cbr\u003e\nPathways\u003cbr\u003e\nARSB is actively involved in the lysosomal degradation pathway one of the key cellular processes for waste removal and recycling of macromolecules. This pathway includes collaboration with other lysosomal enzymes such as iduronate-2-sulfatase to complete the breakdown of complex molecules. ARSB's function in coordination with these enzymes supports cellular maintenance and metabolic balance.\u003cbr\u003e\nARSB malfunction is directly linked to the lysosomal storage disorder Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome) characterized by the accumulation of glycosaminoglycans. This deficiency can lead to several symptoms including skeletal abnormalities and organomegaly. ARSB has also shown relevance in some inflammatory disorders where alterations in glycosaminoglycan breakdown impact cellular communication and tissue homeostasis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854425542825,"sku":"ab85727","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab85727","provider":"Iright","version":"1.0","type":"link"}