{"product_id":"abcam-ab87275","title":"Abcam, ab87275, Anti-MTA3 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MTA3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human MTA3 aa 400-450.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human MTA3 aa 400-450. The exact immunogen used to generate this antibody is proprietary information.Q9BTC8\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nConcentration is optimized for IHC and not determined\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-MTA3 antibody was affinity purified using an epitope specific to MTA3 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe MTA3 protein also known as Metastasis-Associated Protein 3 is a member of the MTA family and has a molecular mass of approximately 53 kDa. MTA3 localizes in the nucleus and shows expression in various tissues including breast tissue and the immune system. It functions as a transcriptional corepressor particularly influencing E-cadherin repression by being part of the nucleosome remodeling and histone deacetylase (NuRD) complex.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nActivities involving gene expression regulation occur through interactions with other chromatin-associated molecules. MTA3 participates as a component of the NuRD complex which also includes Mi2 and HDAC1 that is critical in chromatin remodeling and transcriptional repression. Through MTA3's involvement the complex influences cell proliferation differentiation and epithelial-mesenchymal transition (EMT).\u003cbr\u003e\nPathways\u003cbr\u003e\nMTA3 is particularly significant in the EMT pathway affecting cell migration and invasion capacities. It interacts with proteins such as TWIST and ZEB1 which are associated with EMT. Additionally MTA3 plays a role in the Notch signaling pathway where it helps in maintaining proper cell lineage differentiation by modulating transcription factors through deacetylation processes.\u003cbr\u003e\nAltered MTA3 expression is seen in breast cancer and has a link to its progression. It connects closely with E-cadherin which serves as a marker for EMT and cancer metastasis. MTA3's involvement in histone modification pathways also correlates with altered gene expression seen in various autoimmune disorders making it a possible point of interest for therapeutic research and interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855822344361,"sku":"ab87275","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab87275","provider":"Iright","version":"1.0","type":"link"}