{"product_id":"abcam-ab88304","title":"Abcam, ab88304, Anti-P15RS antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal P15RS antibody. Carrier free. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RPRD1A.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human RPRD1A.Q96P16\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nP15RS also known as CDKN2B-AS1 is a non-coding RNA with a molecular weight of approximately 24 kDa. P15RS functions as a regulator of gene expression and influences various cellular activities. It is expressed in many tissues with notable abundance in the brain heart and skeletal muscles. P15RS plays an important mechanical role in modulating cell cycle progression and can contribute to cellular response to different stimuli.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nP15RS regulates the interaction of proteins involved in apoptosis and cell survival serving as a modulator between these processes. It associates with complexes that control cell cycle transitions particularly at the G1\/S checkpoint. This RNA interacts directly with proteins such as cyclin-dependent kinases affecting their activity and contributing to the balance between cell proliferation and arrest.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis regulatory RNA operates within the p53 signaling pathway and participates in the control of cellular aging and apoptosis. It interacts with proteins like p21 and p27 which are key regulators in these processes. Through these interactions P15RS helps maintain the integrity of cellular mechanisms that govern cell growth and response to DNA damage playing a role in preventing unscheduled progression in the cell cycle.\u003cbr\u003e\nThe dysregulation of P15RS expression has been implicated in cancer especially in correlating with tumor suppressive activity. Alterations in its function can lead to uncontrolled cell proliferation seen in malignancies. In addition to cancer P15RS has associations with cardiovascular diseases where its modulation affects cellular survival under stress conditions. Its interaction with p16 another tumor suppressor highlights its role in maintaining normal cell cycle regulation and potential for its consideration in therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852263608489,"sku":"ab88304","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab88304","provider":"Iright","version":"1.0","type":"link"}