{"product_id":"abcam-ab88519","title":"Abcam, ab88519, Anti-GLUD2 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal GLUD2 antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GLUD2 aa 250 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human GLUD2 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P49448,\u003cbr\u003e\nSpecificity:Due to high sequence homology with GLUD1 there is a potential for cross-reactivity.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGLUD2 also known as glutamate dehydrogenase 2 plays a critical role in the conversion of glutamate to α-ketoglutarate and ammonia facilitated by the NAD+ or NADP+ cofactor. This enzyme belongs to the family of oxidoreductases and has a molecular mass of around 62 kDa. GLUD2 is mainly expressed in the brain specifically in neurons and glial cells reflecting its significant function in central nervous system activities.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGLUD2 is involved in amino acid metabolism and neurotransmitter flux. It participates in balancing nitrogen and carbon important for neurotransmitter release and energy production in neural cells. The enzyme often exists as part of signaling complexes within mitochondria emphasizing its role in cellular energy homeostasis. Through its metabolic activities GLUD2 supports synapses in maintaining cognitive functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nGLUD2 plays important roles in the TCA cycle and glutamine-glutamate cycle. In the TCA cycle it facilitates the entry of nitrogen into the cycle via α-ketoglutarate production directly influencing cellular respiration and ATP generation. Its activity in the glutamine-glutamate cycle links it to interactions with glutaminase affecting synaptic signaling and plasticity which are vital for neural communication.\u003cbr\u003e\nGLUD2 has associations with neurodegenerative conditions and metabolic disorders. Its malfunction contributes to hyperinsulinism-hyperammonemia syndrome and increased risk for certain neuropathologies like Alzheimer's disease. GLUD2's relationship with proteins like glutaminase and other dehydrogenases can influence the progression of these disorders by altering metabolic fluxes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852266983593,"sku":"ab88519","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab88519","provider":"Iright","version":"1.0","type":"link"}