{"product_id":"abcam-ab89260","title":"Abcam, ab89260, Anti-RNF144A antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal RNF144A antibody. Carrier free. Suitable for WB, ICC\/IF and reacts with Rat, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RNF144A.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Rat, Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human RNF144A.P50876\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRNF144A also known as IBRDC3 or MUL1 is an E3 ubiquitin-protein ligase with an approximate mass of 32 kDa. It plays an important role in tagging proteins with ubiquitin molecules marking them for degradation via the proteasome system. RNF144A comprises RING finger domains which facilitate its ligase activity. This protein expresses in a variety of tissues including the heart brain and liver among others. It interacts directly with substrates to ensure protein homeostasis which is important for cellular function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRNF144A influences cellular processes like apoptosis and cell proliferation. It is known to be a component of protein complexes involved in the regulation of these processes. By targeting specific proteins for degradation RNF144A helps control cellular growth and death signals which is essential in maintaining cellular equilibrium. Its activity can impact the levels of pro-apoptotic and anti-apoptotic factors which then influences the fate of the cell.\u003cbr\u003e\nPathways\u003cbr\u003e\nRNF144A functions prominently in the ubiquitin-proteasome pathway and the JAK\/STAT signaling pathway. Within the ubiquitin-proteasome pathway it determines the fate of misfolded or damaged proteins that need removal to prevent cellular dysfunction. In relation to the JAK\/STAT signaling pathway it may influence cytokine signaling by regulating the turnover of pathway components. RNF144A's relationship with these pathways connects it to proteins like JAK kinases and STAT transcription factors which are important for immune responses and cellular signaling.\u003cbr\u003e\nDysfunction in RNF144A activity has links to cancer and neurodegenerative diseases. Aberrant activity of this protein can lead to uncontrolled cell growth which contributes to the development and progression of cancers such as breast cancer. Moreover in neurodegenerative diseases RNF144A may interact with proteins such as Parkin an E3 ligase affected in Parkinson’s disease affecting protein aggregation processes. Understanding RNF144A's roles in these conditions is important for developing targeted therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852267376809,"sku":"ab89260","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab89260","provider":"Iright","version":"1.0","type":"link"}