{"product_id":"abcam-ab89298","title":"Abcam, ab89298, Anti-Puma gamma\/GPR109A antibody [MM0329-6S24]","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRat Monoclonal Puma gamma\/GPR109A antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HCAR2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rat,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:MM0329-6S24,\u003cbr\u003e\nIsotype:IgG2,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human HCAR2.Q8TDS4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-The IgG fraction of culture supernatant was purified by Protein G affinity chromatography., Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPuma gamma also known as GPR109A is a G-protein-coupled receptor with a molecular weight of approximately 39 kDa. This receptor is expressed in various tissues including adipose tissue the immune system and the gastrointestinal tract. Puma gamma is located on the cell surface where it binds to ligands including niacin and butyrate. Binding leads to changes in cellular activities through signaling specifically influencing cellular responses to external stimuli.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGPR109A plays an important role in metabolic processes. This receptor is involved in the regulation of lipolysis in adipocytes thereby controlling fat breakdown. GPR109A is also significant in mediating anti-inflammatory responses. Although it does not form part of a larger complex its signaling affects interactions with other cellular components. These functions contribute to maintaining homeostasis within the body's systems.\u003cbr\u003e\nPathways\u003cbr\u003e\nGPR109A participates in the cAMP signaling pathway which has importance in energy balance and hormone regulation. When GPR109A activates it inhibits adenylyl cyclase reducing cyclic AMP levels. This receptor is also linked to the anti-inflammatory pathways through interactions with cytokines and other immune-modulating proteins. GPR109A's activity connects closely with proteins such as beta-arrestins and GRK which modulate its signaling efficiency and duration.\u003cbr\u003e\nGPR109A has associations with obesity and cardiovascular diseases. High levels of GPR109A expression or dysfunction can lead to increased inflammation contributing to metabolic syndrome and related health problems. This receptor's interaction with niacin is therapeutically targeted in managing dyslipidemia a risk factor for cardiovascular diseases. Additionally research indicates potential links between GPR109A and inflammatory bowel disease through modulation of immune cell activity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855514980521,"sku":"ab89298","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab89298","provider":"Iright","version":"1.0","type":"link"}