{"product_id":"abcam-ab91565","title":"Abcam, ab91565, Anti-EIF2B5 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal EIF2B5 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human EIF2B5 aa 400-450.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human EIF2B5 aa 400-450. The exact immunogen used to generate this antibody is proprietary information.Q13144\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab91565 was affinity purified using an epitope specific to EIF2B5 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEIF2B5 also known as eukaryotic translation initiation factor 2B subunit epsilon plays an important role in the regulation of protein synthesis. It is a catalytic subunit of the larger eIF2B complex which is responsible for guanine nucleotide exchange on eIF2. This protein has a molecular mass of approximately 85 kDa. EIF2B5 is ubiquitously expressed indicating its importance in various tissues. Its role in translation initiation is fundamental in controlling cellular responses to stress and nutrient signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProtein synthesis control by eIF2B5 impacts cell growth and adaptation. As an important component of the eIF2B complex which consists of five different subunits EIF2B5 directly interacts with eIF2 to facilitate GDP-GTP exchange. This process is essential for recycling eIF2 for successive rounds of translation initiation. Proper function of the eIF2B complex ensures cellular capacity to manage stress conditions such as amino acid deprivation or viral infection by modulating protein synthesis rates to conserve resources and adapt.\u003cbr\u003e\nPathways\u003cbr\u003e\nEIF2B5 plays a significant role in the integrated stress response (ISR) pathway. Through its involvement in ISR it links with proteins like eIF2 and integrates signaling from different stressors. This pathway helps in adjusting the translation of specific mRNAs by phosphorylating eIF2 making EIF2B5 essential for the regulation of global and gene-specific translation. Additionally dysfunctions in its regulation may impact the mTOR pathway an important regulator of cell growth in response to nutrient availability although EIF2B5 mainly functions in ISR.\u003cbr\u003e\nMutations in EIF2B5 are associated with leukoencephalopathy with vanishing white matter (VWM) a rare neurological disorder. This condition links EIF2B5 dysfunction to impaired oligodendrocyte maturation and myelination in the brain. Additionally altered functioning of EIF2B5 may relate to other stress-related disorders as its regulatory role in translation impacts cell survival under stress conditions. Connections between eIF2B5 and proteins like eIF2 underline its involvement in proper neuronal function and response to metabolic changes important to understanding disorders like VWM.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848589037737,"sku":"ab91565","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab91565","provider":"Iright","version":"1.0","type":"link"}