{"product_id":"abcam-ab92748","title":"Abcam, ab92748, Recombinant Rat Prorenin protein","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Rat Prorenin protein is a Rat Full Length protein, expressed in HEK 293 cells, with \u0026gt;95%, suitable for SDS-PAGE.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% SDS-PAGE,\u003cbr\u003e\nExpression system:HEK 293 cells,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P08424,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Rat,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.605% Tris\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nProrenin also known as angiotensinogenase is a precursor form of renin. This protein plays a vital role in the renin-angiotensin system (RAS) which regulates blood pressure and electrolyte balance. Prorenin is primarily synthesized in the juxtaglomerular cells of the kidney and possesses a molecular weight of approximately 40 kDa. It exists in an inactive form until it is cleaved to form active renin. It moves through the bloodstream to reach target tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProrenin initiates the conversion of angiotensinogen to angiotensin I an important step in the RAS. In its inactive form prorenin circulates throughout the body but remains ready for activation. The activation involves a non-proteolytic conformational change or proteolytic cleavage within the kidneys. Prorenin may exist as part of a complex with the (pro)renin receptor which influences various physiological processes beyond blood pressure regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis precursor functions as an important regulator within the renin-angiotensin system. Prorenin by forming renin is directly involved with the conversion of angiotensinogen into angiotensin I. This initial step leads to further pathways that construct angiotensin II a potent vasoconstrictor affecting the vascular system. The activity of angiotensin II ties closely to the actions of the enzyme angiotensin-converting enzyme (ACE) which transforms angiotensin I to angiotensin II.\u003cbr\u003e\nProrenin's activation links strongly to conditions such as hypertension and diabetic nephropathy. Elevated prorenin levels have been observed in individuals with hypertension indicating its central role in this disorder. Furthermore its interaction with the (pro)renin receptor contributes to the progression of renal disease in diabetes-related nephropathy. The relationship among prorenin renin and the (pro)renin receptor provides significant implications for therapeutic strategies targeting these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843866251433,"sku":"ab92748","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab92748","provider":"Iright","version":"1.0","type":"link"}