{"product_id":"abcam-ab9286","title":"Abcam, ab9286, Anti-Epithelial Keratin Type I antibody [AE1]","description":"\u003cp\u003eSize: 125µg\u003cbr\u003e\nMouse Monoclonal Epithelial Keratin Type I antibody. Suitable for IHC-P, IHC-Fr, WB and reacts with Mouse, Rat, Rabbit, Chicken, Cow, Monkey, Turtle samples. Cited in 14 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human KRT1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:AE1,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nLight chain type:unknown,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Rabbit, Chicken, Cow, Monkey, Turtle,\u003cbr\u003e\nApplications:IHC-Fr, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Native Full Length Protein corresponding to Human KRT1.P04264\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.3Preservative: 0.1% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEpithelial Keratin Type I also known as cytokeratin or CK is a family of cytoskeletal proteins found in the epithelial cells. These proteins are usually around 40-67 kDa in mass. Epithelial Keratin Type I is essential for structural integrity and mechanical strength of epithelial cells. It mainly expresses in epithelial tissues including skin hair and nails and serves a critical role in forming the intermediate filament network.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese keratins provide stability to cell architecture and protect cells from mechanical and non-mechanical stresses. Epithelial Keratin Type I proteins form heterodimers by pairing with Type II keratins creating filaments that are part of a larger complex. These structures are vital for maintaining the correct function and shape of cells in tissues and they also play a role in cell signaling processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nEpithelial Keratin Type I participates in key pathways like the cytoskeletal signaling and epidermal growth factor (EGF) signaling. These pathways involve interactions with proteins such as keratin 8 and keratin 18. These keratins facilitate communication within cells and help mediate responses to external signals therefore influencing cell proliferation differentiation and apoptosis.\u003cbr\u003e\nMutations or dysfunctions in Epithelial Keratin Type I have links to skin diseases such as epidermolysis bullosa simplex and psoriasis. These conditions can result from altered interactions with other keratins such as keratin 5 and keratin 14 disrupting the normal function and structure of epithelial tissues. Such disorders highlight the importance of Epithelial Keratin Type I in maintaining healthy skin and its barrier functions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845034528937,"sku":"ab9286","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab9286","provider":"Iright","version":"1.0","type":"link"}