{"product_id":"abcam-ab94118","title":"Abcam, ab94118, TLE2 overexpression 293T lysate (whole cell)","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nTLE2 overexpression 293T lysate (whole cell) suitable for WB. View our extensive range of validated lysates from normal and diseased human, mouse and rat tissue.\u003cbr\u003e\nKey facts\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nForm:LiquidSee storage information\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab94118 is a 293T cell transfected lysate in which Human TLE2 has been transiently over-expressed using a pCMV-TLE2 plasmid. The lysate is provided in 1X Sample Buffer.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTLE2 also known as Transducin-Like Enhancer of Split 2 is a member of the Groucho\/TLE family of co-repressors. It has a molecular mass of approximately 82 kDa. TLE2 is expressed in various tissues including brain and muscle. As a protein it interacts with transcription factors repressing transcription by binding to DNA-binding proteins which ultimately influences gene expression and cellular differentiation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTLE2 serves as a general transcriptional co-repressor. It forms complexes with other transcriptional regulators to modulate gene expression participating in the repression of transcriptional activity. TLE2 shows a significant role in embryonic development and neuronal differentiation working alongside other Groucho family members to guide cell fate decisions during development.\u003cbr\u003e\nPathways\u003cbr\u003e\nTLE2 interacts with a range of signaling mechanisms involved in development and differentiation. It is notably involved in the Notch signaling pathway which regulates cell differentiation and proliferation. Additionally TLE2 associates with Wnt signaling interacting with other proteins like LEF1 and TCF to suppress Wnt target genes. These interactions contribute to maintaining a balance between cell proliferation and differentiation.\u003cbr\u003e\nTLE2 has connections to several neurological conditions. Altered expression or function of TLE2 is linked to neurodevelopmental disorders including autism spectrum disorder. Furthermore disruptions in its interaction with other proteins like LEF1 influence pathological processes associated with cancer particularly in brain tumors. Understanding TLE2's role in these conditions helps in unraveling the molecular mechanisms underlying disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845114712233,"sku":"ab94118","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab94118","provider":"Iright","version":"1.0","type":"link"}