{"product_id":"abcam-ab94519","title":"Abcam, ab94519, Recombinant Human CALM1 Protein","description":"\u003cp\u003eSize: 20µg \/ 50µg\u003cbr\u003e\nRecombinant Human CALM1 Protein is a Human Full Length protein, in the 1 to 149 aa range, expressed in Escherichia coli, with \u0026gt;95%, suitable for SDS-PAGE, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:The dilution curve of ab268375 was determined in a CAMK26δ activation assay using autocamtide-2 as substrate.,\u003cbr\u003e\nAccession:P0DP23,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.5Preservative: 1.02% ImidazoleConstituents: 25% Glycerol (glycerin, glycerine), 1.74% Sodium chloride, 0.82% Sodium phosphate, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCalmodulin 1 (CALM1) also known simply as calmodulin is a calcium-binding messenger protein that plays an important role in various cellular processes. Weighing approximately 16.7 kDa CALM1 is structurally important due to its ability to bind calcium ions which causes conformational changes enabling its interaction with other proteins. CALM1 is found in many tissues throughout the body with a significant presence in the brain where it participates in neuronal signaling muscle cells and endocrine tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCALM1 functions as an important component in calcium signaling pathways. It forms a part of several signaling complexes modulating the activity of various enzymes ion channels and other proteins by directly binding to them. Through these interactions CALM1 regulates cellular functions such as metabolism cell division and gene expression. It also plays a role in smooth muscle contraction and neurotransmitter release showcasing its broad impact across different biological systems.\u003cbr\u003e\nPathways\u003cbr\u003e\nCALM1 integrates into important signaling cascades such as the calcium\/calmodulin-dependent protein kinase (CaMK) pathway and the phosphoinositide signaling pathway. These pathways are essential for transmitting calcium signals which control various cellular responses. CALM1 interacts with proteins like CaMK and calcineurin which are vital in regulating processes like muscle contraction and immune responses. Through these pathways CALM1 helps maintain cellular homeostasis and normal physiological functions.\u003cbr\u003e\nCALM1 has connections to a few conditions including cardiac arrhythmias and Alzheimer's disease. Mutations in the CALM1 gene can lead to altered calcium regulation contributing to cardiac arrhythmias due to defective calcium signaling in heart tissues. In Alzheimer's disease dysfunction in calcium signaling might play a role though the exact mechanisms remain under investigation. CALM1's relationship with proteins such as amyloid precursor protein (APP) in Alzheimer's highlights its involvement in pathological processes further demonstrating its importance in health and disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843917566121,"sku":"ab94519","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab94519","provider":"Iright","version":"1.0","type":"link"}