{"product_id":"abcam-ab94966","title":"Abcam, ab94966, Anti-Respiratory Syncytial Virus G Glycoprotein antibody [RSV133]","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nAnti-Respiratory Syncytial Virus G Glycoprotein antibody [RSV133] (ab94966) is a mouse monoclonal antibody detecting Respiratory Syncytial Virus G Glycoprotein in  Western Blot, IHC-Fr, ICC\/IF, ELISA . Suitable for  Respiratory syncytial virus . - Trusted since 2010\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:RSV133,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Respiratory syncytial virus,\u003cbr\u003e\nApplications:ELISA, ICC\/IF, WB, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Respiratory Syncytial Virus G Glycoprotein antibody [RSV133] (ab94966) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-Fr), Immunocytochemistry\/immunofluorescence (ICC\/IF), ELISA in Respiratory syncytial virus samples.\u003cbr\u003e\nWhat is the molecular weight of Respiratory Syncytial Virus G Glycoprotein?\u003cbr\u003e\nAnti-Respiratory Syncytial Virus G Glycoprotein [RSV133] (ab94966) specifically detects a band for Respiratory Syncytial Virus G Glycoprotein (UniProt: P03423) at a molecular weight of 33kDa.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Sodium azideConstituents: 99.98% PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Respiratory Syncytial Virus G Glycoprotein also known as RSV G protein plays a significant mechanical role in the virus's lifecycle. This glycoprotein with a molecular mass of approximately 90 kDa is expressed on the surface of the Respiratory Syncytial Virus (RSV). RSV G protein primarily facilitates viral attachment to host cells by binding to heparan sulfate on the cell surface. This attachment serves as an initial step for viral infection aiding RSV in invading epithelial cells of the respiratory tract.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe RSV G protein contributes to immune evasion and modulation within the host. By mimicking chemokine structures the glycoprotein interferes with host antiviral defenses. It does not form part of a larger protein complex but acts individually to attract leukocytes to the site of infection potentially facilitating immune cell misdirection. This function helps the virus persist in the host and enhances its pathogenicity making the protein a target for anti-RSV strategies.\u003cbr\u003e\nPathways\u003cbr\u003e\nRSV G glycoprotein operates in immune response modulation and viral entry pathways. It interacts with host cell pathways like the chemokine signaling pathway and is relevant to the viral exocytic pathway. Relations to other proteins occur as the glycoprotein's mimicry of chemokines affects the cytokine network. The G protein's action influences the regulation of immune-related proteins which can either promote or restrict infection via cellular signaling alterations.\u003cbr\u003e\nThe RSV G protein is closely connected to diseases such as bronchiolitis and pneumonia. These are common respiratory illnesses particularly in infants and the elderly influenced by RSV infection efficiency. The G glycoprotein's role in immune modulation exacerbates these conditions creating a link to proteins involved in respiratory inflammation such as cytokines and chemokines. Understanding the interplay with these proteins helps in the development of therapeutic strategies to manage RSV-induced respiratory diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860481200297,"sku":"ab94966","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab94966","provider":"Iright","version":"1.0","type":"link"}