{"product_id":"abcam-ab96718","title":"Abcam, ab96718, Anti-OGT \/ O-Linked N-Acetylglucosamine Transferase antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nAnti-OGT \/ O-Linked N-Acetylglucosamine Transferase antibody (ab96718) is a rabbit polyclonal antibody detecting OGT \/ O-Linked N-Acetylglucosamine Transferase in  Western Blot, IP, IHC-P, ICC\/IF . Suitable for  Human, Mouse, Rat, Zebrafish . - Over 30 publications - Trusted since 2010\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human, Zebrafish,\u003cbr\u003e\nApplications:IP, IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human OGT aa 200-500. The exact immunogen used to generate this antibody is proprietary information.O15294\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-OGT \/ O-Linked N-Acetylglucosamine Transferase antibody (ab96718) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Human, Mouse, Rat, Zebrafish samples.\u003cbr\u003e\nWhat is the molecular weight of OGT \/ O-Linked N-Acetylglucosamine Transferase?\u003cbr\u003e\nAnti-OGT \/ O-Linked N-Acetylglucosamine Transferase (ab96718) specifically detects a band for OGT \/ O-Linked N-Acetylglucosamine Transferase (UniProt: O15294) at a molecular weight of 117kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-OGT \/ O-Linked N-Acetylglucosamine Transferase (ab96718) was first used in a scientific publication in 2010 and has been cited over 30 times in peer-reviewed journals.\u003cbr\u003e\nReviewed by scientists\u003cbr\u003e\nAnti-OGT \/ O-Linked N-Acetylglucosamine Transferase (ab96718) has over 10 independent reviews from customers.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOGT or O-Linked N-Acetylglucosamine Transferase also known as OGT protein mechanically catalyzes the addition of N-acetylglucosamine (O-GlcNAc) onto serine or threonine residues of nuclear and cytoplasmic proteins. OGT has a molecular weight of approximately 110 kDa. It is expressed in various tissues with higher levels in the pancreas brain and spleen. This enzyme plays an important role in cellular processes by modifying proteins with O-GlcNAc.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThrough its transferase activity OGT regulates a wide array of cellular functions including signal transduction transcription and metabolism. It is a component of a complex involving several other proteins that facilitate its regulatory actions. OGT manages protein function and stability by influencing interactions between proteins and other cellular components.\u003cbr\u003e\nPathways\u003cbr\u003e\nOGT is critical in the insulin signaling pathway and the regulation of glucose metabolism. It interacts with multiple proteins such as IRS-1 and Akt to modulate their activity and stability. The modification by OGT impacts protein phosphorylation states affecting the downstream processing of cellular signals.\u003cbr\u003e\nOGT has a significant link to diabetes and neurodegenerative diseases like Alzheimer's. Abnormal OGT activity relates to insulin resistance contributing to diabetes pathogenesis. In Alzheimer's disease altered O-GlcNAcylation affects proteins like tau which play a central role in disease progression. Understanding OGT's role in these conditions could aid in developing targeted therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844276211881,"sku":"ab96718","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab96718","provider":"Iright","version":"1.0","type":"link"}