{"product_id":"abcam-ab97953","title":"Abcam, ab97953, Recombinant Human PDXP protein","description":"\u003cp\u003eSize: 50µg \/ 250µg\u003cbr\u003e\nRecombinant Human PDXP protein is a Human Full Length protein, in the 1 to 296 aa range, expressed in Escherichia coli, with \u0026gt;95%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q96GD0,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein pyridoxal phosphate phosphatase also known as PDXP serves as an important enzyme in the regulation of vitamin B6 bioavailability. It carries a mass of approximately 32 kDa. PDXP dephosphorylates pyridoxal 5'-phosphate (PLP) which is the active form of vitamin B6 to pyridoxal (PL). Primarily the expression of PDXP occurs in the cytoplasm and has been detected in various tissues such as brain and liver suggesting its diverse role across different biological systems.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPyridoxal phosphate phosphatase affects many cellular processes by maintaining the balance of pyridoxal 5'-phosphate levels. This enzyme is essential for the regulation of processes that depend on pyridoxal phosphate as a cofactor including amino acid metabolism neurotransmitter synthesis and lipid metabolism. It functions independently rather than being part of a large protein complex allowing its activity to directly influence the availability of pyridoxal phosphate for biochemical reactions.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe role of pyridoxal phosphate phosphatase spans significant metabolic pathways such as the amino acid catabolic pathway. Here it functions alongside enzymes that require pyridoxal 5'-phosphate for activity including transaminases and decarboxylases. Additionally PDXP interacts with proteins like pyridoxal kinase which phosphorylates pyridoxal to replenish PLP maintaining the balance between synthesis and degradation in the metabolic flux.\u003cbr\u003e\nPyridoxal phosphate phosphatase dysregulation can influence neurological and metabolic disorders. For instance altered PDXP activity has been connected to neurological conditions such as epilepsy where it may affect neurotransmitter levels due to insufficient pyridoxal phosphate. Furthermore mutations in genes related to PDXP or its interacting partners such as pyridoxal kinase could contribute to metabolic syndromes due to disrupted vitamin B6 homeostasis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843844624553,"sku":"ab97953","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab97953","provider":"Iright","version":"1.0","type":"link"}