{"product_id":"biolegend-100236","title":"Biolegend, 100236, APC anti-mouse CD3 Antibody, 100μg","description":"\u003cp\u003eCD3, also known as T3, is a member of the Ig superfamily and primarily expressed on T cells, NK-T cells, and at different levels on thymocytes during T cell differentiation. CD3 is composed of CD3ε, δ, γ and ζ chains. It forms a TCR complex by associating with TCR α\/β or γ\/δ chains. CD3 plays a critical role in TCR signal transduction, T cell activation, and antigen recognition by binding the peptide\/MHC antigen complex\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: γδTCR-positive T-T hybridoma D1\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Additional reported application (for relevant formats) include: spatial biology (IBEX)1,2.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed\u003cbr\u003e\nProduct Citations: Koyama M, et al. 2015. J Exp Med. 212: 1303 - 1321. PubMed Morse M, et al. 2016. Lupus. 25: 81 - 87. PubMed Calabrese DR, et al. 2020. J Clin Invest. . PubMed Hou X, et al. 2020. Cell Reports. 28(1):172-189.e7.. PubMed Liu J, et al. 2019. Immunity. 50:600. PubMed Bergmann CA, et al. 2022. Cells. 11:. PubMed Akhtar MN, et al. 2022. MBio. 13:e0330921. PubMed Balakrishnan PB, et al. 2022. Nano Res. 15:2300. PubMed Shi X, et al. 2022. Proc Natl Acad Sci U S A. 119:e2208506119. PubMed Ho HM, et al. 2022. Pharmaceutics. 14:. PubMed Sparbier CE, et al. 2023. Nat Cell Biol. 25:258. PubMed Pan Y, et al. 2023. Adv Sci (Weinh). 10:e2206792. PubMed Wang X, et al. 2023. J Immunother Cancer. 11:. PubMed Liu N, et al. 2023. Cell Death Dis. 14:170. PubMed Gupta T, et al. 2023. Front Immunol. 14:1044703. PubMed Mabire M, et al. 2023. Nat Commun. 14:1830. PubMed Fu S, et al. 2023. Nat Commun. 14:2248. PubMed Li T, et al. 2023. Nat Commun. 14:2498. PubMed Zhang Z, et al. 2023. Aging Dis. 14:966. PubMed Bhaskar A, et al. 2023. iScience. 26:106644. PubMed Changsheng H, et al. 2023. Sci Adv. 9:eade4186. PubMed Cansever D, et al. 2023. Nat Immunol. . PubMed Rivas MA, et al. 2021. Nat Immunol. 22:240. PubMed Xiang G, et al. 2022. Cell Death Dis. 13:451. PubMed Pani F, et al. 2021. Endocrinology. 162:. PubMed Hilfenhaus G, et al. 2021. Cancer Res. 81:619. PubMed Denny L, et al. 2021. Clin Transl Immunology. 10:e1234. PubMed Ramos SA, et al. 2022. J Allergy Clin Immunol. 149:767. PubMed Zhou Y, et al. 2021. Methods Mol Biol. 2388:35. PubMed Sugiura A, et al. 2022. Immunity. 55:65. PubMed Alam A, et al. 2022. Cancer Cell. 40:153. PubMed Cautivo KM, et al. 2022. Immunity. 55:254. PubMed Qi X, et al. 2022. FASEB J. 36:e22250. PubMed van Dierendonck XAMH, et al. 2022. Proc Natl Acad Sci U S A. 119:e2114739119. PubMed Corral D, et al. 2022. Cell Rep. 39:110715. PubMed Tu J, et al. 2022. Cancer Sci. 113:2496. PubMed Dolfi B, et al. 2022. Cell Rep. 39:110949. PubMed Du M, et al. 2022. Cancer Sci. 113:2974. PubMed Tessaro FHG, et al. 2022. Cell Rep. 39:110977. PubMed Grégoire C, et al. 2022. Immunity. 55:1216. PubMed Zhu J, et al. 2022. Research (Wash D C). 2022:9816272. PubMed Zhang Z, et al. 2022. Integr Cancer Ther. 21:15347354221138534. PubMed Miró L, et al. 2022. Cancers (Basel). 14: . PubMed An HW, et al. 2022. Cell Rep. 41:111878. PubMed Jin SM, et al. 2023. Nat Nanotechnol. :. PubMed Lin J, et al. 2023. Nat Commun. 14:224. PubMed Kang J, et al. 2023. JCI Insight. 8: . PubMed Chen Y, et al. 2023. Stem Cells Int. 2023:7482546. PubMed Li X, et al. 2022. Cell. 185:1709. PubMed Naito Y, et al. 2019. American Journal of Physiology-Renal Physiology. 318(1):F238-F247. PubMed Yang H, et al. 2019. Mol Metab. 23:24. PubMed Gabriely G, et al. 2021. iScience. 24:103347. PubMed Delvecchio FR, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:1543. PubMed Kim D, et al. 2021. Nanomicro Lett. 13:31. PubMed Sano T, et al. 2021. Cell Reports. 36:109608. PubMed Wilson RP, et al. 2019. PLoS Pathog. 15:e1007745. PubMed Yu VWC et al. 2016. Cell. 167(5):1310-1322 . PubMed Huang X, et al. 2019. Cancer Immunol Res. 1.388888889. PubMed Gupta SS, et al. 2019. Cell Rep. 29:1862. PubMed Fu X, et al. 2020. J Immunol. 205:2066. PubMed Song J, et al. 2021. J Am Heart Assoc. 10:e017329. PubMed Baram T, et al. 2021. Cells. 10:. PubMed Luo R, et al. 2021. Theranostics. 11:117. PubMed Pessoa Rodrigues C, et al. 2021. Sci Adv. 7:. PubMed Zhang S, et al. 2022. Cell Death Dis. 13:844. PubMed Forte E, et al. 2020. J Cell Mol Med. . PubMed Haque M, et al. 2021. STAR Protoc. 2:100264. PubMed Gruber T, et al. 2020. JCI Insight. 5:00. PubMed Yamamoto R et al. 2018. Cell stem cell. 22(4):600-607 . PubMed Greenberg J, et al. 2022. JCI Insight. Online ahead of print. PubMed Kremenovic M, et al. 2022. J Immunother Cancer. 10:. PubMed Peng Z, et al. 2021. STAR Protocols. 2(2):100595. PubMed Wang X, et al. 2021. Front Cell Dev Biol. 632805:9. PubMed Swidergall M, et al. 2019. Cell Rep. 28:423. PubMed Tsuchiya N, et al. 2020. Cell Reports. 29(1):162-175.e9.. PubMed Fujino T, et al. 2021. Nat Commun. 12:1826. PubMed Shi S, et al. 2020. Clin Cancer Res. 26:5990. PubMed Almutairi F, et al. 2021. Front Immunol. 12:772288. PubMed Magod P, et al. 2021. Cell Reports. 36(5):109480. PubMed Yoshimi A, et al. 2019. Nature. 574:273. PubMed Thomas S, et al. 2019. J Immunother Cancer. 7:214. PubMed Uchimura T et al. 2018. Immunity. 49(6):1049-1061 . PubMed Zhang X, et al. 2022. Pharmaceutics. 14:. PubMed Tang D, et al. 2020. Br J Haematol. 191:906. PubMed van Elsas MJ, et al. 2022. Int J Mol Sci. 23:. PubMed Francian A, et al. 2021. J Drug Target. 29:754. PubMed Antunes KH, et al. 2022. Front Immunol. 13:867022. PubMed Mastandrea I, et al. 2022. STAR Protoc. 3:101106. PubMed Wu G, et al. 2020. Br J Pharmacol. 177:5063. PubMed Zhang Z, et al. 2021. Oncoimmunology. 10:1912472. PubMed Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed Zhang F, et al. 2019. Immunity. 50:738. PubMed Liu H, et al. 2020. Cancer Cell. 37(3):324-339. PubMed Li X, et al. 2020. Mol Ther. 28:2430. PubMed Guo W, et al. 2022. J Immunother Cancer. 10:. PubMed Ren HZ, et al. 2022. J Clin Transl Hepatol. 10:1138. PubMed Utley A, et al. 2020. Cell Rep. 31:107815. PubMed Utz B, et al. 2020. Sci Rep. 10:18733. PubMed Hiramoto T, et al. 2018. Mol Ther. 26:1255. PubMed Yu VWC, et al. 2017. Cell. 168:944. PubMed Wang GZ, et al. 2019. Nat Commun. 10:1125. PubMed Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed Wang W, et al. 2022. Aging Cell. 21:e13630. PubMed Xie Z, et al. 2020. Light Sci Appl. 0.486805556. PubMed Court AC, et al. 2020. EMBO Rep. 21:e48052. PubMed Venturutti L, et al. 2020. Cell. 182(2):297-316.e27. PubMed Zhang W, et al. 2019. Oncol Lett. 17:815. PubMed Schadt L, et al. 2020. Cell Reports. 29(5):1236-1248.e7.. PubMed Hu Q, et al. 2018. Nat Biomed Eng. 0.660416667. PubMed Suryawanshi RK, et al. 2021. Nat Commun. 12:6020. PubMed Du Y, et al. 2022. Nat Commun. 13:231. PubMed Chauveau A, et al. 2020. Immunity. 52:794. PubMed Haikala HM, et al. 2019. Nat Commun. 10:620. PubMed Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed Zuo W, et al. 2022. Cell Death Discov. 8:257. PubMed Reinfeld BI, et al. 2021. Nature. 593:282. PubMed Kruta M, et al. 2021. Cell Stem Cell. :. PubMed Liu Y, et al. 2017. Oncogene. 10.1038\/onc.2017.209. PubMed Hu J, et al. 2019. Mol Ther Nucleic Acids. 16:650. PubMed Burr ML, et al. 2019. Cancer Cell. 36:385. PubMed Liang J, et al. 2020. Sci Adv. 6:eabc3646. PubMed Huang Z, et al. 2021. Nat Commun. 12:145. PubMed Zhu Y, et al. 2021. EMBO J. 40:e105320. PubMed Wang Y, et al. 2021. Front Microbiol. 12:701566. PubMed Zheng D, et al. 2022. Acta Pharm Sin B. 12:2740. PubMed Tomala J, et al. 2020. Methods Mol Biol. 2111:101. PubMed Wen M, et al. 2022. JCI Insight. Online ahead of print. PubMed Stirling ER, et al. 2022. J Immunother Cancer. 10:. PubMed Li H, et al. 2021. Adv Sci (Weinh). 2001596:8. PubMed Tomay F, et al. 2019. J Transl Med. 17:237. PubMed Xiong W, et al. 2022. Adv Sci (Weinh). 9:e2103029. PubMed Xiao L, et al. 2021. Clin Cancer Res. 27:4338. PubMed Huang L, et al. 2021. Breast Cancer Res Treat. Online ahead of print. PubMed Han F, et al. 2020. Invest Ophthalmol Vis Sci. 61:24. PubMed Wang X, et al. 2020. Nat Commun. 4.505555556. PubMed Johnson DC, et al. 2020. Cell Death Dis. 0.894444444. PubMed Evgin L, et al. 2020. Nat Commun. 2.671527778. PubMed Wei Z, et al. 2021. Nat Commun. 0.805555556. PubMed Xu P, et al. 2020. Cancer Immunol Res. 8:1193. PubMed Xi‐Zhi J Guo et al. 2018. Immunity. 49(3):531-544 . PubMed Subramanian K, et al. 2019. Nat Microbiol. 4:62. PubMed Yu H, et al. 2021. Front Oncol. 11:736882. PubMed Chen C, et al. 2021. J Virol. 95:e0082921. PubMed Martinez-Turtos A, et al. 2022. Oncoimmunology. 11:2116844. PubMed Zeng Q, et al. 2022. iScience. 25:105151. PubMed Adnan-Awad S, et al. 2020. Leukemia. . PubMed Liu Y, et al. 2020. Oncol Lett. 2369:20. PubMed Chen R, et al. 2021. Cell Reports. 34(7):108751. PubMed Cianciaruso C, et al. 2020. Cell Reports. 27(10):3062-3080.e11.. PubMed Zhang J, et al. 2018. Nature. 553:91. PubMed Pascual-Pasto G, et al. 2022. J Immunother Cancer. 10:. PubMed Li Z, et al. 2022. Nat Commun. 13:6321. PubMed Olivo Pimentel V, et al. 2021. J Immunother Cancer. 9:. PubMed Li M, et al. 2021. Cancers (Basel). 13:. PubMed Jiang L, et al. 2020. Cell. 183(5):1219-1233.e18. PubMed Yu M, et al. 2021. Molecular Cell. 81(6):1216-1230.e9. PubMed Liu P, et al. 2020. Mol Cell. 748:77. PubMed Nechama M, et al. 2018. Nat Commun. 9:1603. PubMed Liu YG, et al. 2019. FASEB J. 33:5018. PubMed Siddique SM, et al. 2019. Sci Rep. 9:13977. PubMed Kim S, et al. 2020. Autophagy. :1. PubMed Lazarian G, et al. 2021. Cancer Cell. 39(3):380-393.e8. PubMed Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed Olson CA, et al. 2021. Cell Host Microbe. 29:1378. PubMed Li K, et al. 2020. Nat Commun. 4.844444444. PubMed Hering L, et al. 2020. Front Immunol. 1.747222222. PubMed Yoshida S, et al. 2022. PLoS One. 17:e0264317. PubMed Zhong C, et al. 2021. J Virol. 95:e0092521. PubMed Kelley WJ, et al. 2022. JCI Insight. 7: . PubMed Wang Y, et al. 2021. Cell Reports. 36(6):109516. PubMed Hidalgo San Jose L, et al. 2020. Cell Rep. 30:69. PubMed Hao L, et al. 2021. Br J Pharmacol. 178:4726. PubMed Lau P, et al. 2022. Cell Mol Immunol. :. PubMed Arora S, et al. 2021. Med (N Y). 2:938. PubMed Li H, et al. 2022. iScience. 25:104481. PubMed Gardenier J, et al. 2017. Nat Commun. 8:14345. PubMed Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed Zeng A, et al. 2020. Oncol Rep. . PubMed Das A, et al. 2020. J Bone Miner Res. 36:199. PubMed Agelidis A, et al. 2017. Cell Rep. 10.1016\/j.celrep.2017.06.041. PubMed Sartorius R, et al. 2018. Front Immunol. 1.413888889. PubMed Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed Lightman SM, et al. 2020. Cell Reports. 1.086805556. PubMed Kujur W, et al. 2020. PLoS Pathog. 16:e1009132. PubMed Wang X, et al. 2021. Sci Transl Med. 13:. PubMed Rappe JCF, et al. 2021. J Exp Med. 218:. PubMed Lee A, et al. 2022. Nat Commun. 13:549. PubMed Tripathi D, et al. 2016. Nat Commun. 7:13896. PubMed Pessoa Rodrigues C, et al. 2020. Sci Adv. 6:eaaz4815. PubMed Song X, et al. 2022. Transl Oncol. 15:101306. PubMed Akhtar MN, et al. 2020. PLoS Pathog. 16:e1009136. PubMed Zhang J, et al. 2021. Stem Cell Res Ther. 12:579. PubMed Chang MH, et al. 2021. Cell Rep. 37:109902. PubMed Xie Z, et al. 2020. Light Sci Appl. 9:161. PubMed Lake CM, et al. 2021. Cell Death Dis. 12:400. PubMed\u003cbr\u003e\nRRID: AB_2561455 (BioLegend Cat. No. 100235) AB_2561456 (BioLegend Cat. No. 100236)\u003cbr\u003e\nStructure: Ig superfamily, CD3\/TCR, 20 kD\u003cbr\u003e\nDistribution: Thymocytes (differentiation dependent), mature T cells, NK-T cells\u003cbr\u003e\nFunction: Antigen recognition, TCR signal transduction, T cell activation\u003cbr\u003e\nLigand\/Receptor: Peptide antigen\/MHC-complex\u003cbr\u003e\nAntigen References: 1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Davis MM. 1990. Annu. Rev. Biochem. 59:475. 3. Weiss A, et al. 1994. Cell 76:263.\u003cbr\u003e\nGene ID: 12502\u003cbr\u003e\nUniProt: View information about CD3 on UniProt.org\u003cbr\u003e\nClone: 17A2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T cell antigen receptor complex, T3\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860821659817,"sku":"100236","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-100236","provider":"Iright","version":"1.0","type":"link"}