{"product_id":"biolegend-100602","title":"Biolegend, 100602, Purified anti-mouse CD5 Antibody, 500μg","description":"\u003cp\u003eCD5 is a 67 kD protein, also known as Lyt-1, Ly-1, T1, Tp67, or Ly-12. It is a member of the scavenger receptor cysteine-rich protein superfamily (SRCR) and primarily expressed on thymocytes, T cells, and B-1 cells. Although mature α\/β T cells express high levels of CD5, very few γ\/δ T cells express this antigen. The interaction of CD5 with CD72, gp35-37, TCR, or BCR is involved in T and B cell activation.\u003cbr\u003e\n500μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse thymus or spleen\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality testedIHC-F, CyTOF® - VerifiedIHC-P, IP - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunoprecipitation1, and immunohistochemistry2 of acetone-fixed frozen tissue sections, zinc-fixed paraffin-embedded sections and formalin-fixed paraffin-embedded sections.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Ledbetter JA, et al. 1979. Immunol. Rev. 47:63. (IP) Ledbetter JA, et al. 1980. J. Exp. Med. 152:280. (FC, IHC) Bourdeau A, et al. 2007. Blood doi:10.1182\/blood-2006-08-044370.\u003cbr\u003e\nProduct Citations: Michela Miani et al. 2018. Cell metabolism. 28(4):557-572 . PubMed Kang YA, et al. 2023. J Exp Med. 220:. PubMed Seifert HA, et al. 2018. Metab Brain Dis. 33:1599. PubMed Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed Prado C, et al. 2021. J Neuroinflammation. 18:292. PubMed Niss Arfelt K, et al. 2017. Blood. 129:866. PubMed Peng V, et al. 2020. J Biol Chem. 295:14866. PubMed Doorduijn EM, et al. 2018. Front Immunol. 0.416666667. PubMed Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed Formaglio P, et al. 2021. Immunity. 54:2724. PubMed Liu H, et al. 2020. J Immunol. 205:1207. PubMed Sprouse ML, et al. 2018. JCI Insight. 3:e97322. PubMed Lee JY, et al. 2018. Front Immunol. 0.678472222. PubMed Yates K, et al. 2018. Proc Natl Acad Sci U S A. 115:2162. PubMed Wang HC, et al. 2017. J Immunol. 198:3149. PubMed Parigi SM, et al. 2018. Sci Rep. 0.440277778. PubMed Kawabe T, et al. 2017. Sci Immunol. 2:eaam9315. PubMed Goltsev Y et al. 2018. Cell. 174(4):968-981 . PubMed Mohrin M, et al. 2021. Aging Cell. 20:e13313. PubMed Cole C, et al. 2018. Nucleic Acids Res. 46:e62. PubMed Yamashita M, et al. 2019. Cell Stem Cell. 25:357. PubMed Kästele V, et al. 2021. Mucosal Immunol. 14:717. PubMed\u003cbr\u003e\nRRID: AB_312731 (BioLegend Cat. No. 100602)\u003cbr\u003e\nStructure: Member of the scavenger receptor cysteine-rich protein superfamily (SRCR), 67 kD\u003cbr\u003e\nDistribution: Thymocytes, T cells, B-1 cells\u003cbr\u003e\nFunction: Negative regulator of T-B cell interaction\u003cbr\u003e\nLigand\/Receptor: CD72, gp35-37\u003cbr\u003e\nCell Type: B cells, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Kipps TJ. 1988. Adv. Immunol. 47:117. 3. Antin JH, et al. 1985. J. Immunol. 136:505. 4. Tarakhovsky A, et al. 1995. Science 269:535.\u003cbr\u003e\nGene ID: 12507\u003cbr\u003e\nUniProt: View information about CD5 on UniProt.org\u003cbr\u003e\nClone: 53-7.3\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Lyt-1, Ly-1, T1, Tp67, Ly-12\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862441644201,"sku":"100602","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-100602","provider":"Iright","version":"1.0","type":"link"}