{"product_id":"biolegend-107804","title":"Biolegend, 107804, PE anti-mouse CD321 (F11R) Antibody, 100μg","description":"\u003cp\u003eF11R is a cell adhesion molecule and immunoglobulin superfamily member and an important regulator of tight junction assembly in epithelia. It is found on the surface of platelets, and plays a role in platelet aggregation, secretion, adhesion, and spreading. By interacting with integrin alpha-L\/beta-2, it is involved in leukocyte transmigration.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: E14.5 mouse fetal liver cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Sugano Y et al. 2008. Blood. 111(3): 1167–72.\u003cbr\u003e\nRRID: AB_2910281 (BioLegend Cat. No. 107803) AB_2910281 (BioLegend Cat. No. 107804)\u003cbr\u003e\nStructure: 32 kD single pass type I membrane glycoprotein, member of the immunoglobin superfamily\u003cbr\u003e\nDistribution: Cell membrane, tight junctions\u003cbr\u003e\nFunction: Protein homodimerization, integrin binding, PDZ domain binding, tight junction formation\u003cbr\u003e\nInteraction: integrin alpha-L\/beta-2, MPDZ, PARD3, ITGAL\u003cbr\u003e\nLigand\/Receptor: integrin alpha-L\/beta-2\u003cbr\u003e\nCell Type: Endothelial cells, Epithelial cells, Leukocytes, Platelets\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Adhesion, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: Martin-Padura I, et al. 1998. J Cell Biol. 142:117-27. Muller WA. 2003. Trends Immunol. 24:327-34. Kostrewa D, et al. 2001. EMBO J. 20:4391-8.\u003cbr\u003e\nGene ID: O88792\u003cbr\u003e\nUniProt: View information about CD321 on UniProt.org\u003cbr\u003e\nClone: 27-9\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Junctional adhesion molecule-1, Jam-1, Jam-A, junctional adhesion molecule-A, CD321\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860882215081,"sku":"107804","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-107804","provider":"Iright","version":"1.0","type":"link"}