{"product_id":"biolegend-110102","title":"Biolegend, 110102, Purified anti-mouse CD27 Antibody, 100μg","description":"\u003cp\u003eCD27 is also known as S152 and T14. A member of the tumor necrosis factor receptor (TNFR) superfamily, CD27 is a 45 kD protein expressed on peripheral T cells, memory B cells, NK cells, and thymocyte subset. Through its ligand, CD70, CD27 plays a key role in T cell and B cell interactions. Additionally, ligation of CD27 on naïve T cells may be important in their maturation to effector cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse CD27 protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone A18209B can compete with clone LG.3A10 on target cells. Clone A18209B can also block binding of CD70 to CD27 in a cell-based binding assay.\u003cbr\u003e\nRRID: AB_2910285 (BioLegend Cat. No. 110102)\u003cbr\u003e\nStructure: TNFR superfamily, 45 kD\u003cbr\u003e\nDistribution: Peripheral blood T cells, memory B cells, NK cells, thymocytes subset\u003cbr\u003e\nFunction: Costimulatory signal for T and B cell activation, T cell development\u003cbr\u003e\nInteraction: TRAF2, TRAF5, CD27-binding protein (Siva)\u003cbr\u003e\nLigand\/Receptor: CD70\u003cbr\u003e\nCell Type: B cells, Lymphocytes, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Adaptive Immunity, Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Hintzen RQ, et al. 1994. Immunol. Today 15:307-11. Akiba H, et al. 1998. J. Biol. Chem. 273:13353-8. Kobata T, et al. 1995. P. Natl. Acad. Sci. USA 92:11249-53. Camerini D, et al. 1991. J. Immunol. 147:3165-9.\u003cbr\u003e\nGene ID: 21940\u003cbr\u003e\nUniProt: View information about CD27 on UniProt.org\u003cbr\u003e\nClone: A18209B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T14, S152, Tp55, TNFRSF7\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866063687849,"sku":"110102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-110102","provider":"Iright","version":"1.0","type":"link"}