{"product_id":"biolegend-112205","title":"Biolegend, 112205, Alexa Fluor® 647 anti-mouse CD326 (Ep-CAM) Antibody, 25μg","description":"\u003cp\u003eEp-CAM (CD326) mediates calcium-independent homophilic cell to cell adhesion. It may also function as a growth factor receptor. It is thought to be involved in maintaining cells in position during proliferation. Expression of Ep-CAM seems to correlate inversely with the level of E-cadherin (CD324). Ep-CAM is considered important in tumor biology.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested IHC-F - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. For immunohistochemistry on frozen tissue sections, a concentration of 10.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm \/ 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_3683140 (BioLegend Cat. No. 112205) AB_3683140 (BioLegend Cat. No. 112206)\u003cbr\u003e\nStructure: 40 kD single-pass type 1 glycoprotein. 293 amino acids, with a 21 aa signal peptide, a 246 aa extracellular domain, a 21 aa transmembrane domain, and a 26 aa cytoplasmic domain. The extracellular domain contains two epidermal growth factor-like repeats.\u003cbr\u003e\nDistribution: Expressed on majority of epithelial cell membranes with the exception of adult squamous cells of the skin and a few specific epithelial cell types\u003cbr\u003e\nFunction: Mediates calcium-independent homophilic cell-cell adhesion\u003cbr\u003e\nInteraction: CD326 displays hemophilic binding.\u003cbr\u003e\nLigand\/Receptor: CD305 (LAIR-1), CD306 (LAIR-2), and Ep-CAM\u003cbr\u003e\nAntigen References: Borkowski TA, et al. 1996. Eur J Immunol. 26:110-4. Bergsagel PL, et al. 1992. J Immunol. 148:590-6.\u003cbr\u003e\nGene ID: 17075\u003cbr\u003e\nUniProt: View information about CD326 on UniProt.org\u003cbr\u003e\nClone: W20119E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: EGP40, MIC18, TROP1, KSA\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866422071465,"sku":"112205","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-112205","provider":"Iright","version":"1.0","type":"link"}