{"product_id":"biolegend-122202","title":"Biolegend, 122202, Purified anti-mouse IL-21 Antibody, 100μg","description":"\u003cp\u003eInterleukin 21 (IL-21) is a potent immunomodulatory cytokine primarily produced by NKT cells and CD4 + T cells, particularly the inflammatory Th17 subset. It exerts pleiotropic effects on both innate and adaptive immune responses. These include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. IL-21 also has proapoptotic effects on B cells and NK cells. Recent studies have shown that IL-21 functions as an autocrine cytokine, strongly inducing Th17 differentiation and suppressing Foxp3 expression, making it a potential therapeutic target for treating cancer and inflammatory diseases.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2941414 (BioLegend Cat. No. 122202)\u003cbr\u003e\nStructure: Interleukin\u003cbr\u003e\nDistribution: CD4 activated T cells, Th17 cells, Th2 cells\u003cbr\u003e\nFunction: Immunomodulation\u003cbr\u003e\nLigand\/Receptor: IL-21R\u003cbr\u003e\nCell Type: NKT cells, T cells, Tfh, Th17, Th2\u003cbr\u003e\nBiology Area: Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: Parrish-Novak J, et al. 2000. Nature. 408:57-63. Mehta DS, et el. 2004. Immunol Rev. 202:84-95.\u003cbr\u003e\nGene ID: 60505\u003cbr\u003e\nUniProt: View information about IL-21 on UniProt.org\u003cbr\u003e\nClone: S20017B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interleukin-21\u003cbr\u003e\nIsotype: Rat IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866267734185,"sku":"122202","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-122202","provider":"Iright","version":"1.0","type":"link"}