{"product_id":"biolegend-126516","title":"Biolegend, 126516, PE\/Cyanine7 anti-mouse CD183 (CXCR3) Antibody, 100μg","description":"\u003cp\u003eCD183, also known as CXCR3, is a member of the C-X-C chemokine family, characterized by a pair of cysteine residues separated by a single amino acid. CXCR3 is a 38 kD seven pass transmembrane receptor coupled to G-protein. It mediates Ca 2+ mobilization and chemotaxis in response to C-X-C chemokines, such as IP10 (CXCL10), MIG (CXCL9), I-TAC (CXCL11) and PF4 (CXCL4). CXCR3 is expressed primarily on activiated T lymphocytes, NK cells, and some epithelial cells and endothelial cells. It is not expressed on B cells, monocytes, or granulocytes.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Armenian Hamster\u003cbr\u003e\nImmunogen: Mouse N-terminus of CXCR3\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone CXCR3-173 does not work for Western blotting.7 For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 126526) with endotoxin \u0026lt; 0.01 EU\/µg, Azide-Free, 0.2 µm filtered.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Krug A, et al. 2002. J. Immunol. 169:6079. McAleer JP, et al. 2009. J. Immunol. 182:5322. PubMed Sharma R. 2009. J. Immunol. 183:3212. (FC) PubMed Barbi J, et al. 2009. FASEB J. 23:3990. PubMed Kimpfler S, et al. 2009. J. Immunol. 183:6330. PubMed Dürr C, et al. 2010. Cancer Res. 70:10170. (Block) PubMed Uppaluri R, et al. 2008. Transplantation 86:137.\u003cbr\u003e\nProduct Citations: Prota G, et al. 2015. Vaccine. 410: 01290-6. PubMed Christian DA, et al. 2022. Sci Immunol. 7:eabq7432. PubMed Wang D, et al. 2018. Immunity. 48:659. PubMed Amir M, et al. 2018. Cell Rep. 25:3733. PubMed Chen L, et al. 2020. J Exp Med. 217:00:00. PubMed He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed Alves C, et al. 2015. PLoS One. 10: 0142972. PubMed Dietmar Herndler‐Brandstetter et al. 2018. Immunity. 48(4):716-729 . PubMed Nakajima T, et al. 2021. J Exp Med. 218:. PubMed Evgin L, et al. 2020. Nat Commun. 2.671527778. PubMed Phalke SP, et al. 2019. PLoS One. 14:e0218827. PubMed Brenndörfer E, et al. 2014. J Immunol. 192:1671. PubMed Forero A, et al. 2020. Immunity. 51(3):451-464. PubMed Di Pilato M, et al. 2021. Cell. 184(17):4512-4530.e22. PubMed Gaya M et al. 2018. Cell. 172(3):517-533 . PubMed\u003cbr\u003e\nRRID: AB_2086740 (BioLegend Cat. No. 126515) AB_2245493 (BioLegend Cat. No. 126516)\u003cbr\u003e\nDistribution: T cells, plasmacytoid dendritic cells, GM-CSF activated CD34+ hematopoietic progenitors\u003cbr\u003e\nFunction: Essential in T cell recruitment to sites of inflammation\u003cbr\u003e\nCell Type: Dendritic cells, Hematopoietic stem and progenitors, T cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nGene ID: 12766\u003cbr\u003e\nUniProt: View information about CD183 on UniProt.org\u003cbr\u003e\nClone: CXCR3-173\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CXCR3, G protein-coupled receptor 9 (GPR9), CKR-L2, IP10 receptor (IP10-R), Mig receptor (Mig-R )\u003cbr\u003e\nIsotype: Armenian Hamster IgG\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862997848233,"sku":"126516","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-126516","provider":"Iright","version":"1.0","type":"link"}