{"product_id":"biolegend-131902","title":"Biolegend, 131902, Purified anti-mouse IL-21R Antibody, 500μg","description":"\u003cp\u003eThe IL-21R is a member of the cytokine receptor family that closely resembles IL-2R beta and IL-4R alpha. IL-21R is expressed by all mature lymphocytes and up-regulated after B and\/or T cell activation, with the highest expression by activated B cells. A functional IL-21R consists of the IL-21R subunit and the commone gamma-chaiin. Upon binding to IL-21, it activates Jak-1, Jak-3, STAT1, STAT3 and STAT 5 transduction pathway.\u003cbr\u003e\n500μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Rat YB2\/0 hybridoma transfectant cell line expressing truncated IL-21R\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IP - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Jin H, et al. 2004. J. Immunol. 173:657. (FC) Jin H and Malek T. 2006. J. Leukocyte Biol. 80:1416. (FC IP)\u003cbr\u003e\nProduct Citations: Park JY, et al. 2022. Cell Rep. 38:110219. PubMed\u003cbr\u003e\nRRID: AB_1279435 (BioLegend Cat. No. 131902)\u003cbr\u003e\nStructure: A member of the class 1 cytokine receptor family. Show significant sequence and structural homology with the IL-4R alpha chain.\u003cbr\u003e\nDistribution: Express on all mature lymphocytes including B cells, T cells, and NK cells. Reported to be up-regulated upon activation and highest expression on follicular B cells.\u003cbr\u003e\nLigand\/Receptor: IL-21\u003cbr\u003e\nCell Type: B cells, Lymphocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1.Mehta DS, et al. 2004. Immu Reviews 202:84\u003cbr\u003e\nGene ID: 60504\u003cbr\u003e\nUniProt: View information about IL-21R on UniProt.org\u003cbr\u003e\nClone: 4A9\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL-21 Receptor\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862407696553,"sku":"131902","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-131902","provider":"Iright","version":"1.0","type":"link"}