{"product_id":"biolegend-133403","title":"Biolegend, 133403, PE anti-mouse CD267 (TACI) Antibody, 50μg","description":"\u003cp\u003eTransmembrane Activator and CAML Interactor (TACI) is a tumor necrosis factor receptor superfamily (TNFSF) member. It is a type III transmembrane protein sharing a high degree of homology with B cell maturation antigen (BCMA) among TNFSF members. It binds to the ligands BAFF (BLyS) and APRIL. CD267 appears to be particularly important for the regulation of B cell survival and maturation in the spleen. It is a major mediator of BAFF-dependent costimulatory responses in peripheral B cells. Signaling through TACI may serve to down-regulate B cell activity as well. The actual role for TACI in the mouse has still not been fully determined.\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Rat RBL transfected cell line\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per 106 cells in 100 µl. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Siegel RM, et al. 2001. Nat. Immunol. 2:577. Von Bulow GU, et al. 1997. Science 278:138. Yan M, et al. 2001. Nat. Immunol. 2:638. Diaz-de-Durana Y, et al. 2006. Blood 107:594. Moir S, et al. 2012. Blood. 120:4850. PubMed.\u003cbr\u003e\nProduct Citations: Agrafiotis A, et al. 2023. iScience. 26:106055. PubMed Pioli KT, et al. 2023. iScience. 26:106223. PubMed Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed Pack AD, et al. 2021. Cell Reports. 36:109586. PubMed Zhu H, et al. 2019. Nat Commun. 10:1084. PubMed Werner A, et al. 2021. iScience. 24:103076. PubMed Moir S, et al. 2012. Blood. 120:4850. PubMed\u003cbr\u003e\nRRID: AB_2203542 (BioLegend Cat. No. 133403) AB_2240584 (BioLegend Cat. No. 133404)\u003cbr\u003e\nStructure: TACI\/CD267 is a type III transmembrane protein belonging to TNF receptor superfamily (TNFSF). Among TNFSF members, TACI shares a high degree of homology with B cell maturation antigen (BCMA). It binds to the ligands BAFF (BLyS) and APRIL.\u003cbr\u003e\nDistribution: CD267 is expressed predominantly by splenic transitional type 2 and marginal zone B cells, as well as activated B cells. But it is notably absent from germinal center B cells.\u003cbr\u003e\nFunction: CD267 appears to be particularly important for the regulation of B cell survival and maturation in the spleen. It is a major mediator of BAFF-dependent costimulatory responses in peripheral B cells. Signaling through TACI may serve to down-regulate B cell activity.\u003cbr\u003e\nLigand\/Receptor: BAFF (Blys\/TALL-1\/THANK) and APRIL\u003cbr\u003e\nCell Type: B cells\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Ng LG, et al. 2004. J. Immunology. 173:807.\u003cbr\u003e\nGene ID: 57916\u003cbr\u003e\nUniProt: View information about CD267 on UniProt.org\u003cbr\u003e\nClone: 8F10\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TACI\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862494859433,"sku":"133403","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-133403","provider":"Iright","version":"1.0","type":"link"}