{"product_id":"biolegend-135704","title":"Biolegend, 135704, Biotin anti-mouse CD39 Antibody, 100μg","description":"\u003cp\u003eCD39, nucleoside triphosphate diphosphohydrolase-1 (NTPDase 1), is an ectoenzyme that degrades ATP to AMP. It is a member of ectonucleoside triphosphate dihydrolases (E-NTPDases) which are involved in regulation of extracellular nucleotide catabolism and controlling the extracellular nucleoside triphosphate pool (NTP). CD39 is the dominant member of this family in the immune system and involved in suppression of inflammation and control of platelet activation. CD39 is expressed on B cells, dendritic cells, and a subset of T cells including regulatory T cells and memory T cells. The coordinated expression of CD39\/CD73 on Tregs and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops. In human studies, it has been reported that CD4 + CD25 - CD39 + T cells are T inducers.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Purified recombinant mCD39-Ig, mCD39-expressing pcDNA3.1 plasmid, and B cells (CD39+)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested WB, ELISA - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Zhou Q, et al. 2009. Am J. Transplant. 9(10):2303\u003cbr\u003e\nProduct Citations: Browning LM, et al. 2020. Cell Rep. 33:108219. PubMed\u003cbr\u003e\nRRID: AB_2099921 (BioLegend Cat. No. 135703)\u003cbr\u003e\nStructure: A member of ectonucleoside triphosphate dihydrolases (E-NTPDases), an ectoenzyme that degrades ATP to AMP.\u003cbr\u003e\nDistribution: CD39 is expressed on B cells, dendritic cells, and a subset of T cells\u003cbr\u003e\nFunction: CD39 is involved in suppression of inflammation and control of platelet activation. Coordinated expression of CD39\/CD73 on Tregs and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops.\u003cbr\u003e\nCell Type: B cells, Dendritic cells, T cells, Tregs\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Borsellino G et al. 2007. Blood 110(4):1225 2. Deaglio S et al. 2007. J. Exp. Med. 204(6):1257 3. Bynoe MS. et al. 2008. Trends Immunol. 29(3):99 4. Ndhlovu LC. et al. Eur. J. Immunol. 2009 Oct 28. [Epub ahead of print]\u003cbr\u003e\nGene ID: 12495\u003cbr\u003e\nUniProt: View information about CD39 on UniProt.org\u003cbr\u003e\nClone: 5F2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Entpd1, NTPDase1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862461075625,"sku":"135704","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-135704","provider":"Iright","version":"1.0","type":"link"}