{"product_id":"biolegend-136704","title":"Biolegend, 136704, PE anti-mouse CD256 (APRIL) Antibody, 200μg","description":"\u003cp\u003eCD256 (APRIL, TNFSF13, TALL2, TRDL1) a transmembranal protein of 26 kD, forms a homotrimeric molecule that is cleaved from the cell surface resulting in the soluble form of APRIL; it also forms heterotrimers with BLyS. Its receptor are TNFRSF13b\/TACI and TNFRSF17\/BCMA. Expressed by T cells, B cells, dendritic cells, monocytes, and macrophages, APRIL induces proliferation of T and B cells, promotes IgA class switching, downregulates T-cell dependent antibody responses, and regulates the growth of a variety of tumor cells.\u003cbr\u003e\n200μg\u003cbr\u003e\nVerified Reactivity: Mouse, Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Armenian Hamster\u003cbr\u003e\nImmunogen: Fusion protein of murine Maltose binding protein (MBP) and soluble April\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Moreau J, et al. 2015. Blood. 126: 1184-1192. PubMed Wang W, et al. 2014. J Immunol. 192:3011. PubMed\u003cbr\u003e\nRRID: AB_2206542 (BioLegend Cat. No. 136703) AB_2206541 (BioLegend Cat. No. 136704)\u003cbr\u003e\nStructure: Transmembranal protein of 26 kD, forms a homotrimer that is cleaved from the cell surface resulting in the soluble form. forms heterotrimers with BLyS\u003cbr\u003e\nDistribution: T cells, B cells, dendritic cells, monocytes, and macrophages\u003cbr\u003e\nFunction: Induces proliferation of T and B cells, promotes IgA class switching and downregulates T-cell dependent antibody responses, regulates the growth of a variety of tumor cells.\u003cbr\u003e\nLigand\/Receptor: TNFRSF13b\/TACI, TNFRSF17\/BCMA\u003cbr\u003e\nBioactivity: Proliferation, apoptosis inhibition, IgA class switch.\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Macrophages, Monocytes, T cells\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Signal Transduction\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Belnoue E, et al. 2008 Blood 111:2755. 2. Xie P, et al. 2007. Immunity 27:253. 3. Mohr E, et al. 2009. J. Immunol. 182:2113. 4. Tezuka H, et al. 2007. Nature 448:92. 5. Benson MJ, et al. 2008. J. Immunol. 180:3655.\u003cbr\u003e\nGene ID: 69583\u003cbr\u003e\nUniProt: View information about CD256 on UniProt.org\u003cbr\u003e\nClone: A3D8\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TNFSF13, TALL2, TRDL1\u003cbr\u003e\nIsotype: Armenian Hamster IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862523236521,"sku":"136704","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-136704","provider":"Iright","version":"1.0","type":"link"}