{"product_id":"biolegend-137306","title":"Biolegend, 137306, PE anti-mouse\/human CD351 (Fc α\/µ receptor) Antibody, 200μg","description":"\u003cp\u003eFcα\/µ receptor (Fcα\/µR), CD351, is a type I transmembrane protein with an Ig-like domain in extracellular portion.  It is a novel Fc receptor for IgM and IgA.  Fcα\/µ receptor mRNA has been found in thymus, spleen, liver, kidney, intestines, testes, placenta, and T cell leukemia cell lines.  Fcα\/µ receptor protein expression is detected on B cells, macrophages, and activated T cells.  Fcα\/µ receptor mediates primary B lymphocyte endocytosis of IgM-coated Staphylococcus aureus.   It is involved in the primary stages of the immune response to microbes.\u003cbr\u003e\n200μg\u003cbr\u003e\nVerified Reactivity: Mouse, Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: mFcα\/µ receptor transfected Ba\/F3 cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported (for relevant formats) application include: blocking binding of both IgM and IgA to the mFca\/µ receptor2.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Cho Y, et al. 2006. Biochem. Biophys. Res. Commun. 345:474. Shibuya A, et al. 2006. Springer Semin. Immunopathol. 28:377. Anguetil F, et al. 2015. J Immunol. 194:3664. PubMed\u003cbr\u003e\nProduct Citations: Biswas S, et al. 2021. Nature. 591:464. PubMed Anquetil F, et al. 2015. J Immunol. 194:3664. PubMed Legrain S, et al. 2015. J Immunol. 195: 4171 - 4175. PubMed\u003cbr\u003e\nRRID: AB_10550805 (BioLegend Cat. No. 137306)\u003cbr\u003e\nStructure: About 70 kD transmembrane glycoprotein with an Ig-like domain in extracellular portion.\u003cbr\u003e\nDistribution: B cells, macrophages, and activated T cells.\u003cbr\u003e\nFunction: Mediate primary B lymphocyte endocytosis and involve in the primary stages of the immune response to microbes.\u003cbr\u003e\nLigand\/Receptor: IgA and IgM\u003cbr\u003e\nCell Type: B cells, Macrophages, T cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules, Fc Receptors\u003cbr\u003e\nAntigen References: 1. Shibuya A, et al. 2000. Nat. Immunol. 1(5):441. 2. Sandor M, et al. 1992. J. Immunol.. 148(8):2363. 3. Cho Y, et al. 2010. Mol. Immunol. 47(4):878.\u003cbr\u003e\nGene ID: 1412583953\u003cbr\u003e\nUniProt: View information about CD351 on UniProt.org\u003cbr\u003e\nClone: TX61\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: HCDM listed\u003cbr\u003e\nOther Names: Fcα\/μ receptor, Fcα\/μR\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864060842153,"sku":"137306","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-137306","provider":"Iright","version":"1.0","type":"link"}