{"product_id":"biolegend-139606","title":"Biolegend, 139606, PE anti-mouse MAIR-IV (CLM-5) Antibody, 100μg","description":"\u003cp\u003eMAIR-IV, also known as LMIR4 or CLM5, is a member of the myeloid-associated immunoglobulin-like receptor family (MAIR, CD300). It is preferentially expressed on Gr-1 + \/Mac-1 + neutrophils in the peripheral blood, bone marrow, peritoneal cavity, and spleen. It is also found on Mac-1 + \/Gr-1 + macrophages and CD11c + dendritic cells. In association with the immunoreceptor tyrosine based activating motif (ITAM)-bearing adaptor FcRγ, MAIR-IV mediates activation signals for neutrophils.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: MAIR-IV transfected BW5147 cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: Western blot1, plate-coated TX69 induced secretion of IL-6, and TNF-α by neutrophils1.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Nakano T, et al. 2008. Mol. Immunol. 45:289. (Activ, WB)\u003cbr\u003e\nProduct Citations: Nagano N, et al. 2020. Biomedicines. :8. PubMed Graziano VR, et al. 2020. PLoS Pathog. 16:e1008242. PubMed\u003cbr\u003e\nRRID: AB_10641143 (BioLegend Cat. No. 139605)\u003cbr\u003e\nStructure: Ig superfamily, associates with ITAM-bearing adaptor FcRγ\u003cbr\u003e\nDistribution: Neutrophils, macrophages, dendritic cells\u003cbr\u003e\nFunction: Activates neutrophils\u003cbr\u003e\nCell Type: Neutrophils, Macrophages, Dendritic cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Shibuya A, et al. 2009. Immune Network 9:41. 2. Can I, et al. 2008. J. Immunol. 180:207. 3. Nakano T, et al. 2008. Mol. Immunol. 45:289.\u003cbr\u003e\nGene ID: 217305\u003cbr\u003e\nUniProt: View information about MAIR-IV on UniProt.org\u003cbr\u003e\nClone: TX69\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: LMIR4\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864060907689,"sku":"139606","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-139606","provider":"Iright","version":"1.0","type":"link"}