{"product_id":"biolegend-139704","title":"Biolegend, 139704, PE anti-mouse TCR Vβ12 Antibody, 100μg","description":"\u003cp\u003eT cell receptor Vβ12 (TCR Vβ12) is a variant of TCR β chain and, along with TCR α chain, forms the TCR heterodimer. In association with the CD3 complex, TCR α\/β is responsible for antigen recognition through interaction with MHC-peptide complex to initiate the T cell-mediated immune responses. The MR11-1 antibody reacts with the Vβ12 TCR of mice bearing the b haplotype. It has been reported that Mtv-8 and Mtv-9 cause clonally deletion of Vβ12+ T cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Joshi P, et al. 2006. J Leukoc Biol. 80:1345. (FC)\u003cbr\u003e\nProduct Citations: Lui VG, et al. 2024. J Exp Med. :221. PubMed Lee JH, et al. 2022. Cell Rep. 38:110485. PubMed Wang X, et al. 2022. Elife. 11:. PubMed\u003cbr\u003e\nRRID: AB_10643999 (BioLegend Cat. No. 139703) AB_10639729 (BioLegend Cat. No. 139704)\u003cbr\u003e\nStructure: Member of the immunoglobulin superfamily, Vβ12 is a variant of the TCR β chain which associates with the TCR α chain to form the TCR heterodimer\u003cbr\u003e\nDistribution: subset of TCR αβ+ T cells\u003cbr\u003e\nFunction: Recognition of peptides presented in the MHC molecules, responsible for T cell mediated immune responses\u003cbr\u003e\nCell Type: T cells\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immunology\u003cbr\u003e\nMolecular Family: TCRs\u003cbr\u003e\nGene ID: 21577\u003cbr\u003e\nUniProt: View information about TCR Vbeta12 on UniProt.org\u003cbr\u003e\nClone: MR11-1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Vβ12 T-cell receptor, T cell receptor beta 12\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866153144489,"sku":"139704","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-139704","provider":"Iright","version":"1.0","type":"link"}