{"product_id":"biolegend-140003","title":"Biolegend, 140003, PE anti-mouse TCR Vβ6 Antibody, 25μg","description":"\u003cp\u003eVβ6 T cell receptor (TCR Vβ6) is a variant of TCR β chain and, along with TCR α chain, forms the TCR heterodimer. In association with the CD3 complex, TCR α\/β is responsible for antigen recognition in the MHC-Peptide complex and the initiation of the T cell-mediated immune responses. Murine Vβ6 cells recognize the Mtv-7, Mls-1, and rabies superantigens.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: H-Y specific TH Clone OI11\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: induction of T cell proliferation1, blocking in vitro cytolysis1, and in vivo blocking of syngeneic T cell tumor growth2.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Kanagawa O and Palmer EBJ. 1989. Cell. Immunol. 119:412. (Activ, Block) Kanagawa O. 1989. J. Exp. Med. 170:1513. (Block)\u003cbr\u003e\nProduct Citations: Russler-Germain EV, et al. 2021. Immunity. 54:2547. PubMed Sugimoto C, et al. 2022. Elife. 11:. PubMed Russler-Germain EV, et al. 2021. Elife. 10:. PubMed Denzin LK et al. 2017. Immunity. 47(2):310-322 . PubMed Wang X, et al. 2022. Elife. 11:. PubMed\u003cbr\u003e\nRRID: AB_10640727 (BioLegend Cat. No. 140003) AB_10643583 (BioLegend Cat. No. 140004)\u003cbr\u003e\nStructure: Member of the immunoglobulin superfamily, Vβ6 is a variant of the TCR β chain which associates with the TCR α chain to form the TCR heterodimer.\u003cbr\u003e\nDistribution: Expressed on a subset of TCR αβ+ T cells.\u003cbr\u003e\nFunction: Recognition of peptides presented in the MHC molecules, responsible for T cell mediated immune responses.\u003cbr\u003e\nLigand\/Receptor: MHC-Peptide complex\u003cbr\u003e\nCell Type: T cells\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immunology\u003cbr\u003e\nMolecular Family: TCRs\u003cbr\u003e\nAntigen References: 1. Acha-Orbea H and MacDonald HR. 1995. Annu. Rev. Immunol. 13:459. 2. Rudy CK, et al. 1992. J. Exp. Med. 175:1613. 3. Jones LA, et al. 1990. Science 250:1726.\u003cbr\u003e\nGene ID: 21577\u003cbr\u003e\nUniProt: View information about TCR Vbeta6 on UniProt.org\u003cbr\u003e\nClone: RR4-7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T cell receptor beta 6\u003cbr\u003e\nIsotype: Rat IgG2b, λ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866202394793,"sku":"140003","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-140003","provider":"Iright","version":"1.0","type":"link"}