{"product_id":"biolegend-140102","title":"Biolegend, 140102, Purified anti-mouse TCR Vβ8.1, 8.2 Antibody, 100μg","description":"\u003cp\u003eVβ8 T cell receptor (TCR Vβ8) subfamily has three members, Vβ8.1, 8.2, and 8.3. These subfamily members are variants of the TCR β chain that along with the TCR α chain forms the TCR heterodimer, responsible for the recognition of peptides presented by the MHC molecules. Murine Vβ8 + T cells recognize the superantigen staphylococcal enterotoxin B (SEB); in vivo administration of SEB results in the negative selection of Vβ8 + cells in the thymus. Vβ8 is one of the most frequently found β chains on the infiltrating T cells in the brain of mice with experimental autoimmune encephalomyelitis (EAE), and on the T cells response to Toxoplasma gondii .\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: H-Y specific TH Clone OI6\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IHC - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: induction of proliferation of Vβ8.1+ and Vβ8.2+ T cells1,2 and immunohistochemical staining3.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Kanagawa OJ. 1988. J. Immunol. Methods 110:169. (Activ) Denkers EY, et al. 1986. J. Immunol. 156:1089. (Activ) Drescher KM, et al. 2000. Int. Immunol. 12:271. (IHC)\u003cbr\u003e\nRRID: AB_10645511 (BioLegend Cat. No. 140102)\u003cbr\u003e\nStructure: Members of the immunoglobulin superfamily, Vβ8.1 and 8.2 are variants of the TCR β chain which associates with the TCR α chain to form the TCR heterodimer.\u003cbr\u003e\nDistribution: Expressed in a subset of TCR αβ+ T cells\u003cbr\u003e\nFunction: Recognition of peptides presented in the MHC molecules, responsible for T cell mediated immune response\u003cbr\u003e\nLigand\/Receptor: MHC-Peptide complex\u003cbr\u003e\nCell Type: T cells\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immunology\u003cbr\u003e\nMolecular Family: TCRs\u003cbr\u003e\nAntigen References: 1. Marrack P, et al. 2008. Annu. Rev. Immunol. 26:171. 2. Acha-Orbea H and MacDonald HR. 1995. Annu. Rev. Immunol. 13:459. 3. Sim GK and Augustin AA. 1985. Cell 42:89. 4. Mami-Chouaib F, et al. 2002. Immunol. Rev. 188:114.\u003cbr\u003e\nGene ID: 21577\u003cbr\u003e\nUniProt: View information about TCR Vbeta8.1 8.2 on UniProt.org\u003cbr\u003e\nClone: MR5-2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T cell receptor beta 8\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866153373865,"sku":"140102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-140102","provider":"Iright","version":"1.0","type":"link"}