{"product_id":"biolegend-141109","title":"Biolegend, 141109, Pacific Blue™ anti-mouse TCR Vγ1.1\/Cr4 Antibody, 25μg","description":"\u003cp\u003eT cell receptor (TCR) is a heterodimer consisting of an α and β chain (TCR α\/β) or a γ and δ chain (TCR γ\/δ). TCR associates with CD3 to form a CD3\/TCR complex. The CD3\/TCR plays a key role in antigen recognition, signal transduction, and T cell activation. TCR Vγ1.1 (Garman nomenclature) is also called TCR Vγ1 (Tonegawa nomenclature). The Vγ1 gene almost exclusively rearranges to the Jγ4-Cγ4 gene. Vγ1- Jγ4-Cγ4 expressing cells constitute a major population of γ\/δ T cells in the thymus and peripheral lymphoid organs in adult mice, but they are only composed of a minor population of γ\/δ T cells during fetal and early postnatal life. Vγ1 T cell development can happen in thymus-dependent and thymus-independent manners. Further studies have shown that the antibody 2.11 recognizes an epitope located in the Cr4 domain.  Several TCR γ and δ chain nomenclature systems exist. In order to consolidate the various nomenclature systems, we have created charts for corresponding names across some of the most popular naming methods. Click here to see charts . \u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Armenian Hamster\u003cbr\u003e\nImmunogen: T3.13.1 T-cell hybridoma cell line\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Pacific Blue™ under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application. * Pacific Blue™ has a maximum emission of 455 nm when it is excited at 405 nm. Prior to using Pacific Blue™ conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Violet Laser (405 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunoprecipitation1.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Pereira P, et al. 1995. J. Exp. Med. 182:1921. (IP) Pereira P and Boucontet L. 2004. J. Immunol. 173:3261. (FC) Pereira P, et al. 1996. Intl. Immunol. 8:83. (FC)\u003cbr\u003e\nRRID: AB_2750498 (BioLegend Cat. No. 141109) AB_2750499 (BioLegend Cat. No. 141110)\u003cbr\u003e\nStructure: Ig superfamily\u003cbr\u003e\nDistribution: Subset of γ\/δ T-cells\u003cbr\u003e\nFunction: Antigen recognition\u003cbr\u003e\nLigand\/Receptor: Antigen\u003cbr\u003e\nCell Type: T cells\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immunology\u003cbr\u003e\nMolecular Family: TCRs\u003cbr\u003e\nAntigen References: 1. Pereira P, et al. 1995. J. Exp. Med. 182:1921. 2. Grigoriadou K, et al. 2002. J. Immunol. 169:3736.\u003cbr\u003e\nGene ID: 110067\u003cbr\u003e\nUniProt: View information about TCR Vgamma1.1\/Cr4 on UniProt.org\u003cbr\u003e\nClone: 2.11\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T cell receptor Vgamma 1.1, TCR Vγ1 (Tonegawa nomenclature), TCR Cr4, TRGV1, GV5S1\u003cbr\u003e\nIsotype: Armenian Hamster IgG\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860863307945,"sku":"141109","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-141109","provider":"Iright","version":"1.0","type":"link"}