{"product_id":"biolegend-142513","title":"Biolegend, 142513, PE\/Cyanine7 anti-mouse CD138 (Syndecan-1) Antibody, 25μg","description":"\u003cp\u003eCD138, a member of the syndecan protein family, is a type I integral membrane heparin sulfate proteoglycan also known as Syndecan-1. Syndecan-1 participates in cell proliferation, cell migration, and cell matrix adhesion via interaction with collagen, fibronectin, and other soluble molecules (such as FGF-basic). It is expressed on normal and malignant plasma cells, pre-B cells, mesenchymal cells, epithelial cells, and endothelial cells.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse mammary gland epithelial cell line NMuMG\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunohistochemical staining of frozen tissue3 and formalin-fixed paraffin embedded tissue4 and immunofluorescent staining2,3.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Jalkanen M, et al. 1985. J. Cell. Biol. 101:976. (FC) Miettinen H, et al. 1994. J. Cell. Sci. 107:1571. (IF) Li Q, et al. 2002. Cell 111:635. (IF, IHC) McCarthy BA, et al. 2012. BMC Cancer. 12:203. (IHC)\u003cbr\u003e\nProduct Citations: Tan J, et al. 2021. iScience. 24(8):102835. PubMed Wu J et al. 2017. Immunity. 47(6):1114-1128 . PubMed Chen HY, et al. 2022. Elife. 11:. PubMed Daum P, et al. 2023. Front Immunol. 13:991347. PubMed Xu Y, et al. 2022. Nat Commun. 13:980. PubMed Leung W, et al. 2022. Cancer Discov. 12:1782. PubMed Hu Q, et al. 2022. Cell Rep. 40:111035. PubMed McNamara HA, et al. 2020. Cell Host Microbe. 572:28. PubMed Kim CJ, et al. 2018. Immunity. 49:1034. PubMed Baranek T, et al. 2020. Cell Reports. 32(10):108116. PubMed Franks SE, et al. 2019. J Immunol. 202:3381. PubMed Casali P, et al. 2021. Front Immunol. 12:761450. PubMed Chen JS, et al. 2022. Sci Immunol. 7:eabl5652. PubMed Yewdell WT, et al. 2020. Immunity. 53(5):952-970.e11. PubMed Venturutti L, et al. 2020. Cell. 182(2):297-316.e27. PubMed Liu X, et al. 2022. Nat Cancer. :. PubMed Zbesko JC, et al. 2021. Brain Behav Immun. 91:578. PubMed Glaros V, et al. 2021. Immunity. 54:2005. PubMed , et al. 2021. Eur J Immunol. 51:2708. PubMed Fu G, et al. 2021. Nature. 595:724. PubMed Soni C, et al. 2020. Immunity. 52(6):1022-1038.e7. PubMed Noviski M, et al. 2018. Elife. 7:e35074. PubMed Chatterjee D, et al. 2021. Cell Reports. 35(2):108996. PubMed Cuenca M, et al. 2016. J Immunol. 196: 726 - 737. PubMed Wittner J, et al. 2022. Mucosal Immunol. 15:668. PubMed Bello A, et al. 2021. Immunol Cell Biol. 99:879. PubMed Haniuda K, et al. 2020. Cell Rep. 33:108333. PubMed Sanchez HN, et al. 2020. Nat Commun. 0.5. PubMed New JS, et al. 2020. Immunity. 53(1):172-186.e6. PubMed Flümann R, et al. 2021. Cancer Discov. 2:70. PubMed Szodoray P, et al. 2021. Cell Reports. 36(6):109525. PubMed Yoshida H, et al. 2019. Cell. 176:897. PubMed Flümann R, et al. 2021. Blood Cancer Discov. 2:70. PubMed Becktel DA, et al. 2021. J Neurosci. Online ahead of print. PubMed\u003cbr\u003e\nRRID: AB_2562197 (BioLegend Cat. No. 142513) AB_2562198 (BioLegend Cat. No. 142514)\u003cbr\u003e\nStructure: Transmembrane heparan sulfate proteoglycan; member of the syndecan proteoglycan family, 100-200 kD\u003cbr\u003e\nFunction: Cell adhesion, cell motility, cell migration, cell proliferation\u003cbr\u003e\nCell Type: B cells\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Adhesion, Cell Biology, Cell Motility\/Cytoskeleton\/Structure, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Zong F, et al. 2011. PLoS ONE 6:e14816. 2. Yamashita Y, et al. 1999. J. Immunol. 162:5940. 3. Sanderson RD, et al. 1989. Cell. Regul. 1:27.\u003cbr\u003e\nGene ID: 20969\u003cbr\u003e\nUniProt: View information about CD138 on UniProt.org\u003cbr\u003e\nClone: 281-2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Syndecan-1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860884345001,"sku":"142513","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-142513","provider":"Iright","version":"1.0","type":"link"}