{"product_id":"biolegend-146204","title":"Biolegend, 146204, PE anti-mouse CD37 Antibody, 100μg","description":"\u003cp\u003eCD37, also known as Tspan26 is a 40-60 kD member of the tetraspanin (TM4SF) family, with two extracellular regions and both termini in the cytoplasm. CD37 is highly expressed on mature B cells and is also expressed on T cells, monocytes, macrophages, and neutrophils, and dendritic cells to a lesser extent. CD37 forms complexes in the cell membrane with CD53, CD81, CD82, MHC class II and dectin 1. CD37 is essential for B cell survival, regulates T cell proliferation, IgA production, and is involved in dendritic cell migration. CD37 has been described as a promising target in the treatment of B cell malignancies.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Expression vector containing full length mouse CD37 gene\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Hoeger S, et al. 2024. Immunohorizons. 326:8. PubMed\u003cbr\u003e\nRRID: AB_2562285 (BioLegend Cat. No. 146203) AB_2562286 (BioLegend Cat. No. 146204)\u003cbr\u003e\nStructure: Member of the tetraspanin (TM4SF) family, with two extracellular regions, both termini are cytoplasmic, 40-60 kD\u003cbr\u003e\nDistribution: Highly expressed on B cells, low expression on T cells, monocytes, macrophages, neutrophils, and dendritic cells\u003cbr\u003e\nFunction: Essential for B cell survival, regulates T cell proliferation, regulates IgA production, involved in dendritic cell migration\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Neutrophils\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity, Costimulatory Molecules\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Gartlan KH, et al. 2013. Eur. J. Immunol. 43:1208.2. Annemiek B, et al. 2012. Sci. Signal. 5:82.3. van Spriel AB. 2011. Biochem. Soc. Trans. 39:512.4. Heider, KH, et al. 2012. Blood 118:4159.\u003cbr\u003e\nGene ID: 12493\u003cbr\u003e\nUniProt: View information about CD37 on UniProt.org\u003cbr\u003e\nClone: Duno85\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Tspan26, Tetraspanin-26\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46863041003689,"sku":"146204","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-146204","provider":"Iright","version":"1.0","type":"link"}