{"product_id":"biolegend-146303","title":"Biolegend, 146303, Alexa Fluor® 647 anti-mouse IL-17RB Antibody, 25μg","description":"\u003cp\u003eIL-17RB, also known as IL17RH1, belongs to the cytokine receptor family.  IL-17RB possesses a unique intracellular signaling molecule called SEFIR, and is expressed similarily to fibroblast growth factor genes and IL-17R.  It is reported to be expressed on iNKT cells, innate lymphoid cells (ILC), and Th2 cells.  It binds IL-17B and IL-17E (IL-25) but not IL-17A or C.  Its interaction with IL-25 has a higher affinity than that with IL-17B.  Binding of IL-17RB and IL-25\/IL-17E induces NF-kB mediated IL-8 production through interaction with TRAF6 and Act1.  IL-17RB has been reported to play a role in autoimmune diseases such as rheumatoid arthritis and asthma.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse IL-17RB - Fc chimera (human IgG1)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm \/ 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Sasaki T, et al. 2020. Cell Reports. 28(1):202-217.e7.. PubMed Zhu Y, et al. 2021. EMBO J. 40:e105320. PubMed Wang T et al. 2018. Immunity. 49(3):504-514 . PubMed\u003cbr\u003e\nRRID: AB_2562380 (BioLegend Cat. No. 146303) AB_2562381 (BioLegend Cat. No. 146304)\u003cbr\u003e\nStructure: Single pass type I transmembrane protein, 55.9 kD\u003cbr\u003e\nDistribution: iNKT cells, innate lymphoid cells, Th2 cells\u003cbr\u003e\nFunction: Binds IL-25 with higher affinity than IL-17B, can block IL-25 mediated pathology\u003cbr\u003e\nInteraction: TRAF6 and Act1\u003cbr\u003e\nLigand\/Receptor: IL-25\/IL-17E\u003cbr\u003e\nCell Type: NKT cells, Th2\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Hwang SY, et al. 2004. Arthritis Res. Ther. 6:R120. 2. Rickel EA, et al. 2008. J. Immunol. 181:4299. 3. Terashima A, et al. 2008. J. Exp. Med. 205:2727.\u003cbr\u003e\nGene ID: 50905\u003cbr\u003e\nUniProt: View information about IL-17RB on UniProt.org\u003cbr\u003e\nClone: 9B10\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Evi27, IL-17ER, IL17RH1, IL17br, IL-17 receptor B\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862502953129,"sku":"146303","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-146303","provider":"Iright","version":"1.0","type":"link"}