{"product_id":"biolegend-146516","title":"Biolegend, 146516, Biotin anti-mouse CD184 (CXCR4) Antibody, 100μg","description":"\u003cp\u003eCD184, also known as CXCR4, is a member of the G protein coupled receptor family that binds CXCL12 (SDF1). CXCR4 and CXCL12 play an important role in immune and inflammatory responses through the regulation of cell migration and growth. CXCR4 plays a crucial role in the pathogenesis of several autoimmune diseases such as atherosclerosis, rheumatoid arthritis, and wound healing. In addition, CXCR4 is the cofactor for fusion and entry of the T cell-tropic form of HIV-1.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse CXCR4-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: in vivo blocking1\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Costa MJ, et al. 2018. PLoS One. 13:e0194688 (Block) PubMed\u003cbr\u003e\nProduct Citations: Almada AE, et al. 2021. Cell Reports. 34(4):108656. PubMed Stewart I et al. 2018. Immunity. 49(3):477-489 . PubMed Shimba A et al. 2018. Immunity. 48(2):286-298 . PubMed\u003cbr\u003e\nRRID: AB_2650787 (BioLegend Cat. No. 146516)\u003cbr\u003e\nStructure: G-protein-coupled seven transmembrane receptor, 39.7 kD\u003cbr\u003e\nDistribution: T lymphocytes, monocytes, macrophages, tissue-committed stem\/progenitor cells (TCSCs), mast cells, vascular smooth muscle cells (VSMCs)\u003cbr\u003e\nFunction: Development of cardiovascular and central nervous system, hematopoiesis, and colonization of BM by fetal liver-derived hematopoietic stem cells (HSCs) during embryogenesis, homing and egress of CD34+ CXCR4+ progenitor cells from bone marrow, and their migration into peripheral tissues. Critical role in homing of cancer cells to specific metastatic sites. Possible role in the ubiquitin proteosome system.\u003cbr\u003e\nInteraction: Robo -1\u003cbr\u003e\nLigand\/Receptor: CXCL12 (SDF-1)\u003cbr\u003e\nCell Type: Macrophages, Mast cells, Mesenchymal Stem Cells, Monocytes, Neural Stem Cells, T cells\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Cell Motility\/Cytoskeleton\/Structure, Immunology, Neuroscience, Neuroscience Cell Markers, Signal Transduction, Stem Cells, Ubiquitin\/Protein Degradation\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: 1. Kucia M, et al. 2005. Stem Cells 23:879. 2. Muller A, et al. 2001. Nature 410:50. 3. Saini V, et al. 2010. J. Biol. Chem. 285:15566. 4. Prasad A, et al. 2007. J. Leuko. Biol. 82:465. 5. De Klerck B, et al. 2005. Arthritis Res. Ther. 7:R1208. 6. Rueda P, et al. 2008. PLoS One 3:e2543. 7. Feng Y, et al. 1996. Science 272:872.\u003cbr\u003e\nGene ID: 12767\u003cbr\u003e\nUniProt: View information about CD184 on UniProt.org\u003cbr\u003e\nClone: L276F12\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Fusin, LESTR, Sdf1r, Cmkar4, PB-CKR, PBSF\/SDF-1\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866119983273,"sku":"146516","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-146516","provider":"Iright","version":"1.0","type":"link"}