{"product_id":"biolegend-146528","title":"Biolegend, 146528, KIRAVIA Blue 520™ anti-mouse CD184 (CXCR4) Antibody, 100μg","description":"\u003cp\u003eCD184, also known as CXCR4, is a member of the G protein coupled receptor family that binds CXCL12 (SDF1). CXCR4 and CXCL12 play an important role in immune and inflammatory responses through the regulation of cell migration and growth. CXCR4 plays a crucial role in the pathogenesis of several autoimmune diseases such as atherosclerosis, rheumatoid arthritis, and wound healing. In addition, CXCR4 is the cofactor for fusion and entry of the T cell-tropic form of HIV-1.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse CXCR4-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with KIRAVIA Blue 520™ under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. * KIRAVIA Blue 520™ has an excitation maximum of 495 nm, and a maximum emission of 520 nm. KIRAVIA Blue™ 520 is a trademark of Sony. This product is subject to proprietary rights of Sony and is made and sold under license from Sony Corporation. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.Sony and the Sony logo are registered trademarks of Sony Corporation.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: in vivo blocking1\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Costa MJ, et al. 2018. PLoS One. 13:e0194688 (Block) PubMed\u003cbr\u003e\nRRID: AB_3106213 (BioLegend Cat. No. 146527) AB_3106213 (BioLegend Cat. No. 146528)\u003cbr\u003e\nStructure: G-protein-coupled seven transmembrane receptor, 39.7 kD\u003cbr\u003e\nDistribution: T lymphocytes, monocytes, macrophages, tissue-committed stem\/progenitor cells (TCSCs), mast cells, vascular smooth muscle cells (VSMCs)\u003cbr\u003e\nFunction: Development of cardiovascular and central nervous system, hematopoiesis, and colonization of BM by fetal liver-derived hematopoietic stem cells (HSCs) during embryogenesis, homing and egress of CD34+ CXCR4+ progenitor cells from bone marrow, and their migration into peripheral tissues. Critical role in homing of cancer cells to specific metastatic sites. Possible role in the ubiquitin proteosome system.\u003cbr\u003e\nInteraction: Robo -1\u003cbr\u003e\nLigand\/Receptor: CXCL12 (SDF-1)\u003cbr\u003e\nCell Type: Macrophages, Mast cells, Mesenchymal Stem Cells, Monocytes, Neural Stem Cells, T cells\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Cell Motility\/Cytoskeleton\/Structure, Immunology, Neuroscience, Neuroscience Cell Markers, Signal Transduction, Stem Cells, Ubiquitin\/Protein Degradation\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: 1. Kucia M, et al. 2005. Stem Cells 23:879. 2. Muller A, et al. 2001. Nature 410:50. 3. Saini V, et al. 2010. J. Biol. Chem. 285:15566. 4. Prasad A, et al. 2007. J. Leuko. Biol. 82:465. 5. De Klerck B, et al. 2005. Arthritis Res. Ther. 7:R1208. 6. Rueda P, et al. 2008. PLoS One 3:e2543. 7. Feng Y, et al. 1996. Science 272:872.\u003cbr\u003e\nGene ID: 12767\u003cbr\u003e\nUniProt: View information about CD184 on UniProt.org\u003cbr\u003e\nClone: L276F12\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Fusin, LESTR, Sdf1r, Cmkar4, PB-CKR, PBSF\/SDF-1\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866119884969,"sku":"146528","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-146528","provider":"Iright","version":"1.0","type":"link"}