{"product_id":"biolegend-149103","title":"Biolegend, 149103, PE anti-mouse CCL5 (RANTES) Antibody, 25μg","description":"\u003cp\u003eChemokine (C-C motif) ligand 5 (CCL5), also known as regulated on activation, normal T cell expressed and secreted (RANTES), is a 10 kD protein primarily produced by CD8 + T cells. CCL5 can also be secreted by platelets, dendritic cells (DCs), and fibroblasts. CCL5 functions as a chemoattractant for T cells, monocytes, and eosinophils through binding of its receptor, CCR5. CCL5 can inhibit binding of HIV-1 to CCR5 and inhibit HIV-1 entry.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant CCL5\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Jubin V, et al. 2012. Immunol. Res. 52:284.\u003cbr\u003e\nProduct Citations: Soon MSF, et al. 2020. Nat Immunol. 1.984027778. PubMed Tian L, et al. 2022. Nat Cancer. 3:1318. PubMed Hailemichael Y, et al. 2022. Cancer Cell. 40:509. PubMed Mogilenko DA, et al. 2020. Immunity. 54(1):99-115.e12. PubMed McLane LM, et al. 2021. Cell Reports. 35(6):109120. PubMed Böttcher JP, et al. 2018. Cell. 172:1022. PubMed Mamedov MR, et al. 2018. Immunity. 48:350. PubMed Todorov H, et al. 2022. iScience. 25:104927. PubMed Tsubaki T, et al. 2018. Oncotarget. 9:11209. PubMed Collins N, et al. 2016. Nat Commun. 7:11514. PubMed Kim SJ, et al. 2020. Cell Mol Immunol. 17:728. PubMed Sung PS, et al. 2022. JCI Insight. :. PubMed\u003cbr\u003e\nRRID: AB_2564405 (BioLegend Cat. No. 149103) AB_2564406 (BioLegend Cat. No. 149104)\u003cbr\u003e\nStructure: Chemokine (C-C motif) ligand 5, 10 kD\u003cbr\u003e\nDistribution: CD8+ T cells, platelets, DCs, and fibroblasts.\u003cbr\u003e\nFunction: Chemoattractant for T cells, monocytes, and eosinophils.\u003cbr\u003e\nLigand\/Receptor: CCR5, CCR3, and CCR1.\u003cbr\u003e\nCell Type: Dendritic cells, Monocytes, Macrophages, Granulocytes, B cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Schall TJ. 1991. Cytokine 3:165. 2. Schall TJ, et al. 1992. Eur. J. Immunol. 6:1477. 3. Son MH, et al. 2014. Biochem. Biophys. Res. Commun. 450:30.\u003cbr\u003e\nGene ID: 20304\u003cbr\u003e\nUniProt: View information about CCL5 on UniProt.org\u003cbr\u003e\nClone: 2E9\/CCL5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CCL5, SISd, Scya5, RANTES, TCP228\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862322041001,"sku":"149103","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-149103","provider":"Iright","version":"1.0","type":"link"}