{"product_id":"biolegend-150008","title":"Biolegend, 150008, APC anti-mouse Blimp-1 Antibody, 100μg","description":"\u003cp\u003eBlimp-1, also known as PRDM1, is a 98 kD protein containing 5 Kruppel-type zinc finger domains. Blimp-1 represses the transcription factors BCL6 and c-Myc. It is the master regulator of terminal B cell differentiation and is also involved in the differentiation and homeostasis of T cells and natural killer (NK) cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Amino acids 255-395 from mouse Blimp-1 fused with GST.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular flow cytometry using our True-Nuclear™ Transcription Factor Staining Protocol. For flow cytometric staining, the suggested use of this reagent is ≤ 0.06 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: NOTE: For flow cytometric staining with this clone, True-Nuclear™ Transcription Factor Buffer Set (Cat. No. 424401) offers improved staining and is highly recommended.\u003cbr\u003e\nProduct Citations: Dean JW 2023. Cell Reports. 42(1):111963. PubMed Marro BS, et al. 2019. Cell Rep. 29:3293. PubMed Pioli PD, et al. 2020. Immunity. 51(2):351-366. PubMed Shafiei-Jahani P, et al. 2021. Nat Commun. 12:2526. PubMed Si J, et al. 2020. Cancer Cell. 38(4):551-566.e11. PubMed\u003cbr\u003e\nRRID: AB_2728186 (BioLegend Cat. No. 150007) AB_2728187 (BioLegend Cat. No. 150008)\u003cbr\u003e\nStructure: Five Kruppel-type zinc finger domains, 98 kD.\u003cbr\u003e\nDistribution: Plasma cells, CD4+ and CD8+ effector\/memory T cells, and natural killer cells.\u003cbr\u003e\nFunction: Terminal differentiation of B cells, effector\/memory T cells, role in natural killer cells (NK) and T cell homeostasis, and repressor of BCL6 and c-Myc.\u003cbr\u003e\nCell Type: Plasma cells, T cells, NK cells, B cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Transcription Factors\u003cbr\u003e\nAntigen References: 1. Nakaki F, et al. 2013. Nature 501:222. 2. Crotty S, et al. 2010. Nat. Immunol. 11:114. 3. Zhao WL, et al. 2008. Blood 111:3867. 4. Climmino L, et al. 2008. J. Immunol. 181:2338. 5. Martins, G and Clarne, K. 2008. Annu. Rev. Immunol. 26:133.\u003cbr\u003e\nGene ID: 12142\u003cbr\u003e\nUniProt: View information about Blimp-1 on UniProt.org\u003cbr\u003e\nClone: 5E7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: PR domain zinc finger protein 1, B lymphocyte-induced maturation protein-1, PRDM1, BLIMP1, PRDI-BF1, ZNFPR1A1, PRDM-1, BLIMP1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864147087529,"sku":"150008","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-150008","provider":"Iright","version":"1.0","type":"link"}