{"product_id":"biolegend-150302","title":"Biolegend, 150302, Purified anti-mouse CD198 (CCR8) Antibody, 100μg","description":"\u003cp\u003eC-C chemokine receptor type 8 (CCR8) CD198, is a 41 kD G-protein coupled receptor with 7 transmembrane regions. CCR8 is expressed by a subset of thymocytes, Tregs, NKT and Th2-polarized cells, a subset of macrophages, monocytes, and monocyte-derived dendritic cells. CCR8 mediates chemotaxis toward its ligand CCL1, and is involved in apoptosis of thymocytes.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse CD198 (CCR8)-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Scortegagna M, et al. 2020. Nat Commun. 11:99. PubMed\u003cbr\u003e\nRRID: AB_2566246 (BioLegend Cat. No. 150302)\u003cbr\u003e\nStructure: G-protein coupled receptor, 7 transmembrane regions, 41 kD.\u003cbr\u003e\nDistribution: Thymocytes, Tregs, NKT and Th2-polarized cells, subset of macrophages, monocytes and monocyte-derived dendritic cells.\u003cbr\u003e\nFunction: Chemotaxis, involved in thymocyte apoptosis\u003cbr\u003e\nLigand\/Receptor: CCL1 (SCY1,TCA-3)\u003cbr\u003e\nCell Type: Dendritic cells, Macrophages, Monocytes, NKT cells, Th2, Thymocytes, Tregs\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: 1. Coghill JM, et al. 2013. Blood. 122:825. 2. Islam SA, et al. 2011. Nat. Immunol. 12:167. 3. Hoshino A, et al. 2007. J. Immunol. 178:5296. 3. Qu C, et al. 2004. J. Exp. Med. 200:1231.\u003cbr\u003e\nGene ID: 12776\u003cbr\u003e\nUniProt: View information about CD198 on UniProt.org\u003cbr\u003e\nClone: SA214G2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CDw198, C-C chemokine receptor type 8, CKR-8, CC-CKR-8, Ter1\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866285854889,"sku":"150302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-150302","provider":"Iright","version":"1.0","type":"link"}