{"product_id":"biolegend-151702","title":"Biolegend, 151702, Purified anti-mouse CD365 (Tim-1) Antibody, 100μg","description":"\u003cp\u003eCD365 (Tim-1) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-1 and hepatitis virus cellular receptor 1. It is developmentally expressed at high levels in the blastocyst. Tim-1 is expressed on activated CD4 + lymphocytes especially on Th2 cells and has been implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-1 is hepatitis A virus receptor in humans. Tim-4 is the endogenous ligand of Tim-1. The interaction of Tim-1 and Tim-4 is involved in costimulation of T cell proliferation. Tim-1 is an endogenous ligand for LMIR5\/CD300b.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse TIM-1 (igV domain) FC chimera IFA\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality testedDirect ELISA - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.75 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Fonseca JA, et al. 2016. PLoS One. e0154819:11. PubMed Wagner AK, et al. 2017. Nat Commun. 8:15627. PubMed\u003cbr\u003e\nRRID: AB_2616785 (BioLegend Cat. No. 151702)\u003cbr\u003e\nStructure: Transmembrane protein containing immunoglobulin domain and mucin-like domain with the predicted molecular weight of 33 kD.\u003cbr\u003e\nDistribution: Developmentally regulated; highly expressed in embryonic development in blastocysts. Expressed on activated CD4+ lymphocytes, especially Th2 cell lines.\u003cbr\u003e\nFunction: Binds hepatitis virus, may play a critical role in immune responses and the development of atopic diseases (in particular airway hyperreactivity).\u003cbr\u003e\nLigand\/Receptor: Binds hepatitis A virus in humans, Tim-4, and LMIR5\/CD300b.\u003cbr\u003e\nBiology Area: Cell Biology, Cell Proliferation and Viability, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, TCRs\u003cbr\u003e\nAntigen References: 1. McIntire JJ, et al. 2001. Nat. Immunol. 2:1109. 2. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454. 3. Wills-Karp M, et al. 2001. Nat. Rev. Immunol. 1:69. 4. Meyers JH, et al. 2005. Nat. Immunol. 6(5):455. 5. Umetsu S, et al. 2005. Nat. Immunol. 6:447. 6. Lee HH, et al. 2010. J. Immunol. 185:5225.\u003cbr\u003e\nGene ID: 171283\u003cbr\u003e\nUniProt: View information about CD365 on UniProt.org\u003cbr\u003e\nClone: 3B3\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T cell immunoglobulin and mucin domain containing protein-1, T cell and airway phenotype regulator (Tapr), hepatitic virus cellular receptor 1, CD365\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862387216553,"sku":"151702","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-151702","provider":"Iright","version":"1.0","type":"link"}