{"product_id":"biolegend-152004","title":"Biolegend, 152004, APC anti-mouse CD319 Antibody, 100μg","description":"\u003cp\u003eCD319\/CD319\/CS1\/CRACC\/SLAMF7 is a 66 kD transmembrane protein belonging to the CD2 subset of the immunoglobulin superfamily; it is expressed on most NK cells, B cells, and subsets of T cells. CD319 activates immune responses in NK cells when coupled with SAP-family adaptors (SAP, EAT-2, ERT) and inhibits immune responses in the absence of SAP-family adaptors or when bound to SH-domain molecules.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: CD319-Fc fusion protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Bugaut H, et al. 2024. J Exp Med. :221. PubMed Guenther C, et al. 2024. Front Immunol. 1434030:15. PubMed\u003cbr\u003e\nRRID: AB_2632674 (BioLegend Cat. No. 152003) AB_2632675 (BioLegend Cat. No. 152004)\u003cbr\u003e\nStructure: Extracellular domain with one Ig like V-set domain and one Ig like C2-set domain, and an cytoplasmic domain with two immunoreceptor tyrosine-based switch motifs ITSMs.\u003cbr\u003e\nDistribution: Spleen, lymph node, bone marrow, testis, thymus; NK cells, B cells, and subsets of T cells.\u003cbr\u003e\nFunction: Activates immune responses in NK cells when coupled with SAP-family adaptors (SAP, EAT-2, ERT).\u003cbr\u003e\nInteraction: Interacts (via ITSM phosphorylated on Tyr-302) with SH2D1B, PTPN6\/SHP-1, PTPN11\/SHP-2, INPP5D\/SHIP1, CSK and FYN, and SAP-family adaptors (SAP, EAT-2, ERT).\u003cbr\u003e\nCell Type: B cells, NK cells, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Li Y, et al. 2013. PLoS One 8(9):e76681. 2. Dongre P, et al. 2013. Mol. Immunol. 54:254-63. 3. Tovar V, et al. 2002. Immunogenetics 54:394. 4. Dong Z, et al. 2009. Nat. Immunol. 10:973.\u003cbr\u003e\nGene ID: 75345\u003cbr\u003e\nUniProt: View information about CD319 on UniProt.org\u003cbr\u003e\nClone: 4G2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: 19A, CS1, CD319, CRACC, SLAMF7\u003cbr\u003e\nIsotype: Rat IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862416314537,"sku":"152004","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-152004","provider":"Iright","version":"1.0","type":"link"}