{"product_id":"biolegend-153007","title":"Biolegend, 153007, Alexa Fluor® 647 anti-mouse\/human CD282 (TLR2) Recombinant Antibody, 25μg","description":"\u003cp\u003eCD282 (Toll-like receptor 2, TLR2) is an 85kDa, type I transmembrane protein, with 14 leucine-rich repeats (LRR) in the extracellular domain and a toll\/IL-1R (TIR) in the cytoplasmic region. TLR2 is expressed by monocytes\/macrophages, dendritic cells, granulocytes, endothelial cell and epithelial cells. TLR2 associates with TLR1 and TLR6 in the cell surface and is involved in the recognition of pathogen-associated molecular patterns (PAMPs) such as peptidoglycan, lipoteihoic acid (LTA), lipoarabinomanan, lipoproteins, and LPS from certain Gram-negative bacteria, yeast, spirochete and fungi.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse, Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant extracellular domain of murine TLR2\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm \/ 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Blocking of IL-6 and TNF-a production induced by P3CSK4 on RAW264.7 cells was observed during development.\u003cbr\u003e\nProduct Citations: Brina D, et al. 2023. Nat Cancer. 1102:4. PubMed Korin B, et al. 2020. Sleep. :43. PubMed\u003cbr\u003e\nRRID: AB_2728207 (BioLegend Cat. No. 153007) AB_2728208 (BioLegend Cat. No. 153008)\u003cbr\u003e\nStructure: Type I transmembrane protein, 14 leucine-rich repeats (LRR) in the extracellular domain, the intracellular domain contains a toll\/IL-1R (TIR) domain.\u003cbr\u003e\nDistribution: Monocytes\/macrophages, dendritic cells, granulocytes, endothelial cell, epithelial cells.\u003cbr\u003e\nFunction: Activates innate host defense, induces production of pro-inflammatory cytokines.\u003cbr\u003e\nInteraction: TLR1, TLR6 , MYD88 and TRAF6.\u003cbr\u003e\nLigand\/Receptor: Peptidoglycan, lipoteihoic acid (LTA), lipoarabinomanan, lipoproteins, as well as different LPS from certain Gram-negative bacteria, yeast, spirochete and fungi.\u003cbr\u003e\nCell Type: Dendritic cells, Endothelial cells, Epithelial cells, Granulocytes, Macrophages, Monocytes, Neutrophils\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Signal Transduction\u003cbr\u003e\nMolecular Family: CD Molecules, Toll Like Receptors\u003cbr\u003e\nAntigen References: 1. Biswas S, et al. 2016. Blood. 127:2618. 2. Wang Y, et al. 2016. Proc. Natl. Acad. Sci. USA 113:884. 3. Ramstead AG, et al. 2016. Infect. Immun. 84:940. 4. Scheeren FA, et al. 2014. Nat. Cell. Biol. 16:1238. 5. Barbalat R, et al. 2009. Nat. Immunol. 10:1200.\u003cbr\u003e\nGene ID: 240887097\u003cbr\u003e\nUniProt: View information about CD282 on UniProt.org\u003cbr\u003e\nClone: QA16A01\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Toll-like receptor 2, TLR-2, TIL4, CD282, TLR2\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866167922857,"sku":"153007","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-153007","provider":"Iright","version":"1.0","type":"link"}