{"product_id":"biolegend-153512","title":"Biolegend, 153512, PE\/Dazzle™ 594 anti-mouse CD215 (IL-15Rα) Antibody, 100μg","description":"\u003cp\u003eIL-15 receptor α (IL-15Rα) is a cytokine receptor with the structural homology to IL-2Rα (CD25). Both α receptors contain a group of β sandwich protein called sushi domains. Similar to IL-2Rα, IL-15Rα is able to form a heterotrimer with their β chain (CD122) and common γ chain (γc, CD132). But unlike IL-2Rα subunit, IL-15Rα itself binds to IL-15 with equivalent high affinity compared with the heterotrimeric complex. IL-15Rα is expressed as soluble or transmembrane forms by variety cells, such as activated monocytes, dendritic cells, CD8+ memory T cells, NK or NKT cells. IL-15Rα by itself forms stable complexes with IL-15 on cell surface and presents IL-15 in trans to neighboring cells. IL-15, like IL-2, is a pleiotropic four-helix bundle cytokine and plays a key role in promoting T and B cell survival and proliferation, preferentially in memory CD8 + T cell proliferation, and NK\/NKT cell development.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse CD215 recombinant protein (33-205 a.a.)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Dazzle™ 594 under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. * PE\/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_2922479 (BioLegend Cat. No. 153511) AB_2922479 (BioLegend Cat. No. 153512)\u003cbr\u003e\nStructure: IL-15 receptor α (IL-15Rα) is a cytokine receptor with the structural homology of IL-2Rα (CD25). Both α receptors contain a group of β sandwich protein called sushi domains.\u003cbr\u003e\nDistribution: It is found on a variety of subsets including dendritic cells, activated monocytes, memory CD8 T cells and NK\/NKT cells.\u003cbr\u003e\nFunction: IL-15Rα is involved in T and B cell proliferation and development, preferentially for memory CD8+ T cell proliferation, and NK\/NKT cell development\u003cbr\u003e\nLigand\/Receptor: IL-15\u003cbr\u003e\nCell Type: Dendritic cells, Monocytes, NK cells, NKT cells, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Giri JG, et al. 1995. EMBO J. 14:3654. 2. Giron-Michel J, et al. 2005. Blood. 106:2302. 3. Lorenzen I, et al. 2005. J. Biol. Chem. 281:6642. 4. Sato N, et al. 2007. Proc. Natl. Acad. Sci. USA. 104:588. 5. Anderson BG, Quinn LS. 2016. Endocrinology. 157:1315\u003cbr\u003e\nGene ID: 16169\u003cbr\u003e\nUniProt: View information about CD215 on UniProt.org\u003cbr\u003e\nClone: 6B4C88\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL-15RA, IL-15Rα, IL-15 Receptor α subunity\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864375611561,"sku":"153512","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-153512","provider":"Iright","version":"1.0","type":"link"}