{"product_id":"biolegend-153805","title":"Biolegend, 153805, PE anti-mouse CD184 (CXCR4) Recombinant Antibody, 25μg","description":"\u003cp\u003eCD184, also known as CXCR4, is a member of the G protein coupled receptor family that binds CXCL12 (SDF1). CXCR4 and CXCL12 play an important role in immune and inflammatory responses through the regulation of cell migration and growth. CXCR4 plays a crucial role in the pathogenesis of several autoimmune diseases such as atherosclerosis, rheumatoid arthritis, and wound healing. In addition, CXCR4 is the cofactor for fusion and entry of the T cell-tropic form of HIV-1.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Mouse CXCR4-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: This recombinant antibody clone is derived from clone L276F12.\u003cbr\u003e\nProduct Citations: Zhu L, et al. 2024. J Neuroinflammation. 112:21. PubMed Purvis GSD, et al. 2022. Br J Pharmacol. 179:2754. PubMed\u003cbr\u003e\nRRID: AB_2734225 (BioLegend Cat. No. 153805) AB_2734226 (BioLegend Cat. No. 153806)\u003cbr\u003e\nStructure: G-protein-coupled seven transmembrane receptor, 39.7 kD\u003cbr\u003e\nDistribution: T lymphocytes, monocytes, macrophages, tissue-committed stem\/progenitor cells (TCSCs), mast cells, vascular smooth muscle cells (VSMCs)\u003cbr\u003e\nFunction: Development of cardiovascular and central nervous system, hematopoiesis, and colonization of BM by fetal liver-derived hematopoietic stem cells (HSCs) during embryogenesis, homing and egress of CD34+ CXCR4+ progenitor cells from bone marrow, and their migration into peripheral tissues. Critical role in homing of cancer cells to specific metastatic sites. Possible role in the ubiquitin proteosome system.\u003cbr\u003e\nInteraction: Robo -1\u003cbr\u003e\nLigand\/Receptor: CXCL12 (SDF-1)\u003cbr\u003e\nCell Type: Macrophages, Mast cells, Monocytes, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: McDermott DH, et al. 2015. Cell. 160:686 Beck TC, et al. 2014. J Exp Med. 211:2567 Ding BS, et al. 2014. Nature. 505:97 Balabanian K, et al. 2012. Blood. 119:5722\u003cbr\u003e\nGene ID: 12767\u003cbr\u003e\nUniProt: View information about CD184 on UniProt.org\u003cbr\u003e\nClone: QA16A08\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Fusin, LESTR, Sdf1r, Cmkar4, PB-CKR, PBSF\/SDF-1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866173853865,"sku":"153805","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-153805","provider":"Iright","version":"1.0","type":"link"}