{"product_id":"biolegend-156302","title":"Biolegend, 156302, Purified anti-mouse TCR vβ8.3 Antibody, 500μg","description":"\u003cp\u003eThe TCR Vβ8 family consists of three members, namely Vβ8.1, 8.2 and 8.3. 1B3.3 reacts with Vβ8.3 only, but not Vβ8.1 or Vβ8.2. Most mouse strains have about 20% Vβ8+ T cells in the periphery. However, C57BR, C57L, SJL, SWR (Tcra haplotype) and RIII strains (Tcrc haplotype) do not express Vβ8 due to a gene deletion at the Vβ8 loci.  Exogenous superantigen, such as staphylococcal enterotoxin B, stimulates lymphocytes bearing Vβ8 and selectively eliminate those T cells in vivo .\u003cbr\u003e\n500μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Armenian Hamster\u003cbr\u003e\nImmunogen: 3.L2 T Cell Clone Expressing the vβ8.3 TCR\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone 1B3.3 recognizes TCR vß8.3 from both C57BL\/6 and BALB\/c strains.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Kersh G, et al. 1998. J. Immunol. 161:585.\u003cbr\u003e\nProduct Citations: Garrido C, et al. 2016. Front Immunol. 356:7. PubMed\u003cbr\u003e\nRRID: AB_2750428 (BioLegend Cat. No. 156302)\u003cbr\u003e\nStructure: Ig super family; TCR is an 85-kd hetero-dimer composed of alpha and beta chain.\u003cbr\u003e\nDistribution: Expressed in a subset of αβ T cells\u003cbr\u003e\nFunction: Recognition of Peptide\/MHC, T cell activation\u003cbr\u003e\nInteraction: CD3\u003cbr\u003e\nLigand\/Receptor: Peptide\/MHC complex\u003cbr\u003e\nCell Targets: CD3\u003cbr\u003e\nCell Type: T cells\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immunology\u003cbr\u003e\nMolecular Family: TCRs\u003cbr\u003e\nAntigen References: Haskins K, et al. 1984. J. Exp. Med. 160:452 Davis MM, et al. 1998. Annu Rev Immunol. 16:523 Kersh GJ, et al. 1998. J Immunol. 161:585. Tomonari K. 1996. Immunogenetics. 44:73\u003cbr\u003e\nGene ID: 21577\u003cbr\u003e\nUniProt: View information about TCR Vbeta8.3 on UniProt.org\u003cbr\u003e\nClone: 1B3.3\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Tib, TCRB, TCRbeta\u003cbr\u003e\nIsotype: Armenian Hamster IgG\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860845285545,"sku":"156302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-156302","provider":"Iright","version":"1.0","type":"link"}