{"product_id":"biolegend-156534","title":"Biolegend, 156534, Spark Red™ 718 anti-mouse NK-1.1 Antibody, 100μg","description":"\u003cp\u003eNK-1.1 surface antigen, also known as CD161b\/CD161c and Ly-55, is encoded by the NKR-P1B\/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL\/6, FVB\/N, and NZB, but not AKR, BALB\/c, CBA\/J, C3H, DBA\/1, DBA\/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo . NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Mouse NK1.1-transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Spark Red™ 718 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. * Spark Red™ 718 has a maximum excitation of 697 nm and a maximum emission of 711 nm.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Clone S17016D cross-blocks anti-mouse NK1.1 clone PK136, and can stain for NK1.1 post-formaldehyde and methanol-based fixation based on in-house testing.\u003cbr\u003e\nRRID: AB_2924486 (BioLegend Cat. No. 156533) AB_2924486 (BioLegend Cat. No. 156534)\u003cbr\u003e\nStructure: NKR-P1 gene family\u003cbr\u003e\nDistribution: NK and NK-T cells in the NK1.1 mouse strains (C57BL, FVB\/N, NZB)\u003cbr\u003e\nFunction: NK cell activation, IFN-γ production, cytotoxic granule release\u003cbr\u003e\nCell Type: NK cells, NKT cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nAntigen References: Lanier LL. 1997. Immunity 6:371. Yokoyama WM, Seaman WE. 1993. Annu. Rev. Immunol. 11:613. Koo GC, et al. 1986. J. Immunol. 137:3742. Giorda R, Trucco M. 1991. J. Immunol. 147:1701.\u003cbr\u003e\nGene ID: 17059\u003cbr\u003e\nUniProt: View information about NK-1.1 on UniProt.org\u003cbr\u003e\nClone: S17016D\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: NKR-P1C, NKR-P1B, Ly-55, CD161b, CD161c\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866236113065,"sku":"156534","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-156534","provider":"Iright","version":"1.0","type":"link"}