{"product_id":"biolegend-156804","title":"Biolegend, 156804, Alexa Fluor® 647 anti-mouse CLEC4F Antibody, 100μg","description":"\u003cp\u003eCLEC4F, also known as Kupffer cell receptor or KCR, is an 80 kDa type II transmembrane glycoprotein of the C-type lectin superfamily. It is expressed on resident Kupffer cells and infiltrating monocytes in the liver but not on macrophages in other tissues. CLEC4F interacts with alpha-galactosylceramide (α-GalCer) in a calcium-dependent manner and participates in the presentation of α-GalCer to natural killer T (NKT) cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: IHC-F - Quality tested 3D IHC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a concentration range of 2.5 - 10 µg\/mL is suggested. For 3D immunohistochemistry on formalin-fixed tissues, a concentration of 5.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm \/ 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Zeng J, et al. 2023. Nat Commun. 14:2573. PubMed Shang Y, et al. 2022. Br J Pharmacol. 179:4378. PubMed Chen WS, et al. 2021. Cell Rep. 37:109974. PubMed Glennon EKK, et al. 2022. Front Cell Infect Microbiol. 11:804186. PubMed Lam P, et al. 2022. Mol Ther Methods Clin Dev. 26:413. PubMed Cho CS, et al. 2021. Cell. 184(13):3559-3572.e22. PubMed\u003cbr\u003e\nRRID: AB_2814081 (BioLegend Cat. No. 156803) AB_2814082 (BioLegend Cat. No. 156804)\u003cbr\u003e\nStructure: Type II transmembrane glycoprotein\u003cbr\u003e\nDistribution: Kupffer cells\u003cbr\u003e\nFunction: Modulates glycolipids presentation on Kupffer cells.\u003cbr\u003e\nLigand\/Receptor: Fucose, Galactose, N-acetylgalactosamine, un-sialylated glucosphingolipids with GalNAc or Gal terminus\u003cbr\u003e\nAntigen References: Yang CY, et al. 2013. PLoS One. 8(6):e65070. van der Tuin SJL, et al. 2018. J Am Heart Assoc. 7(6) Hsieh SL, et al. 2009. J. Immunol. 182:78.38.\u003cbr\u003e\nGene ID: 51811\u003cbr\u003e\nUniProt: View information about CLEC4F on UniProt.org\u003cbr\u003e\nClone: 3E3F9\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: C-Type Lectin Domain Family 4 Member F (CLEC4F), C-Type Lectin, Superfamily Member 13 (CLECSF13), Kupffer cell receptor (KCR), KCLR\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862394163369,"sku":"156804","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-156804","provider":"Iright","version":"1.0","type":"link"}