{"product_id":"biolegend-157906","title":"Biolegend, 157906, APC anti-mouse CD218a (IL-18Rα) Antibody, 100μg","description":"\u003cp\u003eThe IL-18 receptor (IL-18R) complex is composed of two known chains, IL-18 receptor α (IL-18Rα) and IL-18 receptor β (IL-18Rβ). IL-18Rα (IL-1R5) is an IL-1 receptor super family member. It was originally described as IL-1 receptor-related protein (IL-1Rrp) because of its homology with the IL-1\/Toll receptor family. IL-18Rα is the extracellular binding domain of the IL-18 receptor complex. It is expressed on the majority of peripheral CD4 + T cells, Th1 cells, and reciprocally repressed during Th2 development. The expression of IL-18Rα is induced by an IL-12\/Stat4 pathway and inhibited by IL-4\/Stat6 pathway. Binding of IL-18Rα together with IL-18β to proinflammatory cytokine IL-18 plays an important role in innate and autoimmune responses.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse CD218a\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Shibata K, et al. 2022. Nat Commun. 13:6948. PubMed\u003cbr\u003e\nRRID: AB_2860734 (BioLegend Cat. No. 157905) AB_2860735 (BioLegend Cat. No. 157906)\u003cbr\u003e\nStructure: An IL-1 receptor super family member\u003cbr\u003e\nDistribution: Expressed on T cells, NK cell subset, neutrophils, IL-12 stimulated tonsillar B cells, and intestinal epithelial cells (IEC).\u003cbr\u003e\nFunction: Bind to pro inflammatory cytokine IL-18 and play an important role in innate and autoimmune responses.\u003cbr\u003e\nLigand\/Receptor: IL-18\u003cbr\u003e\nCell Type: B cells, Endothelial cells, Neutrophils, NK cells, T cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: Parnet P, et al. 1996. J. Biol. Chem. 271:3967. Thomassen E, et al. 1998. J. Interferon Cytokine Res. 18:1077-88. Debets R, et al. 2000. J. Immunol. 165:4950-6. Smeltz RB, et al. 2001. J. Exp. Med. 194:143-53.\u003cbr\u003e\nGene ID: 16182\u003cbr\u003e\nUniProt: View information about CD218a on UniProt.org\u003cbr\u003e\nClone: A17071D\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL-1 Rrp, CDw218a, IL-18 receptor a\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866044879017,"sku":"157906","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-157906","provider":"Iright","version":"1.0","type":"link"}