{"product_id":"biolegend-159206","title":"Biolegend, 159206, Spark Red™ 718 anti-mouse CD86 Antibody, 100μg","description":"\u003cp\u003eCD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse CD86\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Spark Red™ 718 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. * Spark Red™ 718 has a maximum excitation of 697 nm and a maximum emission of 711 nm.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Clone A17199A is able to completely block the binding of clone PO3 to CD86.\u003cbr\u003e\nRRID: AB_2936727 (BioLegend Cat. No. 159205) AB_2936727 (BioLegend Cat. No. 159206)\u003cbr\u003e\nStructure: Ig superfamily, 80 kD\u003cbr\u003e\nDistribution: B cells and T cells (upregulated upon activation), macrophages, dendritic cells, and astrocytes\u003cbr\u003e\nFunction: T cell costimulation, Ig class-switching, NK cell cytotoxicity\u003cbr\u003e\nInteraction: Astrocytes, B cells, Dendritic cells, Macrophages, T cells, Tregs\u003cbr\u003e\nLigand\/Receptor: CD28, CD152 (CTLA-4)\u003cbr\u003e\nCell Type: Astrocytes, B cells, Dendritic cells, Macrophages, T cells, Tregs\u003cbr\u003e\nBiology Area: Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: CD Molecules, Immune Checkpoint Receptors\u003cbr\u003e\nAntigen References: Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. Hathcock KS, et al. 1993. Science 262:905. Freeman GJ, et al. 1993. Science 262:907. Carreno BM and Collins M. 2002. Annu. Rev. Immunol. 20:29.\u003cbr\u003e\nGene ID: 16182\u003cbr\u003e\nUniProt: View information about CD86 on UniProt.org\u003cbr\u003e\nClone: A17199A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: B7-2, B70, Ly-58\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866057003177,"sku":"159206","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-159206","provider":"Iright","version":"1.0","type":"link"}